antibody

a1B Calcium Channel

MBS395853

10 Miniblots

440 USD

polyclonal

rabbit

nonconjugated

Antibody

a1B Calcium Channel

a1B Calcium Channel

Voltage-gated calcium channel subunit alpha Cav2.2; Calcium channel; L type; alpha-1 polypeptide isoform 5; Brain calcium channel III

voltage-dependent N-type calcium channel subunit alpha-1B isoform 1; Voltage-dependent N-type calcium channel subunit alpha-1B; voltage-dependent N-type calcium channel subunit alpha-1B; calcium channel, N type; brain calcium channel III; Cav2.2 voltage-gated Ca2+ channel; calcium channel alpha12.2 subunit; calcium channel, L type, alpha-1 polypeptide; voltage-gated calcium channel alpha subunit Cav2.2; voltage-gated calcium channel subunit alpha Cav2.2; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, alpha 1B subunit, N type; calcium channel, voltage-dependent, N type, alpha 1B subunit; Brain calcium channel III; BIII; Calcium channel, L type, alpha-1 polypeptide isoform 5; Voltage-gated calcium channel subunit alpha Cav2.2

CACNA1B; CACNA1B; BIII; CACNN; Cav2.2; CACNL1A5; CACH5; CACNL1A5; BIII

CAC1B_HUMAN

Polyclonal

IgG

Rabbit

Human

2339

Antigen Immunoaffiinity Purification

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Western Blot (WB)

Immunogen: Synthetic peptide derived from the rat alpha1B calcium channel conjugated to KLH

Positive Control: Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.

Antigen Immunoaffinity Purified Polyclonal; Ion Channels

Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1b gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by omega-conotoxin-GVIA (omega-ctx-GVIA) and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to dihydropyridines (dhp), and omega-agatoxin-IVA (omega- aga-IVA). Calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.

4502523

NP_000709.1

NM_000718.3

Q00975

262 kDa

Calcium Regulation In The Cardiac Cell Pathway 198906!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Cholinergic Synapse Pathway 217716!!Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway 106517!!Dopaminergic Synapse Pathway 469199!!Dopaminergic Synapse Pathway 469185!!GABAergic Synapse Pathway 377263!!GABAergic Synapse Pathway 377129!!MAPK Signaling Pathway 83048

The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Subunit structure: Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1 and RIMBP2 . By similarity. Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. Post-translational modification: Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK . By similarity. Sequence similarities: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily. [View classification]Contains 1 EF-hand domain.

10 Miniblots

440 USD