antibody

b3 Calcium Channel

MBS395803

0.1 mg

340 USD

polyclonal

rabbit

nonconjugated

Antibody

b3 Calcium Channel

[b3 Calcium Channel]

[Voltage-Dependent L-Type Calcium Channel; beta3 subunit]

[voltage-dependent L-type calcium channel subunit beta-3 isoform 1; Voltage-dependent L-type calcium channel subunit beta-3; voltage-dependent L-type calcium channel subunit beta-3; calcium channel, voltage-dependent, beta 3 subunit; Calcium channel voltage-dependent subunit beta 3]

[CACNB3; CACNB3; CAB3; CACNLB3; CACNLB3; CAB3]

CACB3_HUMAN

Polyclonal

IgG

Rabbit

Human

484

Ammonium Sulfate Precipitation

Unconjugated. Provided as solution in phosphate buffered saline with 0.08% sodium azide

Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles. Products are stable for one year from purchase when stored properly. Shipping: Ships at ambient temperature, freeze upon arrival

Western Blotting

This antibody can be used for Western blotting (5-10 ug/ml). Optimal concentration should be evaluated by serial dilutions.

Immunogen: Synthetic peptide derived from the rat beta3 calcium channel conjugated to KLH

Positive Control: Rat brain lysate

Polyclonal Antibody; Ion Channels

Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3.

40316928

NP_000716.2

NM_000725.3

P54284

Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Calcium Regulation In The Cardiac Cell Pathway (198906); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway (106517); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494)

This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]

Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Subunit structure: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4. Interacts with FASLG. Ref.9 Ref.10. Tissue specificity: Expressed mostly in brain, smooth muscle and ovary. Sequence similarities: Belongs to the calcium channel beta subunit family.Contains 1 SH3 domain.

0.1 mg

340 USD