antibody

DAP12

MBS395757

0.1 mg

340 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, immunoprecipitation

Antibody

DAP12

[DAP12]

[TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12; Killer-activating receptor-associated protein; KARAP; TYROBP]

[TYRO protein tyrosine kinase-binding protein; TYRO protein tyrosine kinase-binding protein; TYRO protein tyrosine kinase-binding protein; KAR-associated protein; DNAX-activation protein 12; killer-activating receptor-associated protein; killer cell activating receptor associated protein; TYRO protein tyrosine kinase binding protein; DNAX-activation protein 12; Killer-activating receptor-associated protein]

[DAP12]

[Tyrobp; Tyrobp; Ly83; DAP12; KARAP; Dap12; Karap; KAR-associated protein]

TYOBP_MOUSE

Polyclonal

Rabbit

Human, Mouse

114

Ammonium Sulfate Precipitation

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles.

Western Blot (WB), Immunoprecipitation (IP)

Western Blot/Blotting

Immunogen: Recombinant DAP12 protein

Positive Control: NKp44 positive cells. Form: unconjugated

Polyclonal Antibody; Protein Kinases

DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).

6755915

NP_035792.1

NM_011662.2

O54885

12,367 Da

Axon Guidance Pathway (820230); Cell-Cell Communication Pathway (820268); DAP12 Interactions Pathway (819675); DAP12 Signaling Pathway (819676); Developmental Biology Pathway (820229); Immune System Pathway (819567); Innate Immune System Pathway (819596); Natural Killer Cell Mediated Cytotoxicity Pathway (83276); Natural Killer Cell Mediated Cytotoxicity Pathway (490); Osteoclast Differentiation Pathway (193149)

Function: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Ref.7. Subunit structure: Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with SIGLEC14 . By similarity. Interacts with CLECSF5. Interacts with CD300LB and CD300D. Interacts with CD300E. Interacts with KLRC2 and KIR2DS3 . By similarity. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophils and macrophages integrin-mediated activation. Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10. Subcellular location: Membrane; Single-pass type I membrane protein. Post-translational modification: Tyrosine phosphorylated. Sequence similarities: Belongs to the TYROBP family.Contains 1 ITAM domain.

0.1 mg

340 USD