a1A Calcium Channel | MyBioSource MBS395469 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

a1A Calcium Channel

catalog :

MBS395469

quantity :

0.1 mg

price :

315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS395469

products type :

Antibody

products full name :

a1A Calcium Channel

products short name :

a1A Calcium Channel

products name syn :

Voltage-gated calcium channel subunit alpha Cav2.1,Calcium channel; L type; alpha-1 polypeptide; isoform 4; Brain calcium channel I

other names :

voltage-dependent P/Q-type calcium channel subunit alpha-1A; Voltage-dependent P/Q-type calcium channel subunit alpha-1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A; BI; RBA-I; brain class A; brain calcium channel 1; brain calcium channel I; calcium channel alpha 1A; voltage-gated calcium channel subunit alpha Cav2.1; calcium channel, voltage-dependent, alpha 1A subunit; calcium channel, L type, alpha-1 polypeptide, isoform 4; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; Brain calcium channel I; BI; Calcium channel, L type, alpha-1 polypeptide, isoform 4; Rat brain class A; RBA-I; Voltage-gated calcium channel subunit alpha Cav2.1

other gene names :

Cacna1a; Cacna1a; BccA1; rbA-1; Cav2.1; Cach4; Cacn3; Cacnl1a4; BI; RBA-I

uniprot entry name :

CAC1A_RAT

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Rat

sequence length :

2368

purity :

Ammonium Sulfate Precipitation

form :

Provided as solution in phosphate buffered saline with 0.08% sodium azide

storage stability :

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

tested application :

Western Blot (WB)

other info1 :

Immunogen: Synthetic peptide derived from the rat 1A calcium channel conjugated to KLH

other info2 :

Positive Control: Rat brain lysate

products categories :

Polyclonal Antibody; Ion Channels

products description :

Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1a gives rise to p and/or q-type calcium currents. P/q-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin-IVA (omega-aga-IVA). They are however insensitive to dihydropyridines (dhp), and omega- conotoxin-GVIA (omega-ctx-GVIA). voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

ncbi gi num :

158138501

ncbi acc num :

NP_037050.2

ncbi gb acc num :

NM_012918.3

uniprot acc num :

P54282

ncbi mol weight :

251.5 kDa

ncbi pathways :

Calcium Regulation In The Cardiac Cell Pathway (198495); Calcium Signaling Pathway (83442); Calcium Signaling Pathway (459); Cholinergic Synapse Pathway (217713); Dopaminergic Synapse Pathway (469193); Dopaminergic Synapse Pathway (469185); GABAergic Synapse Pathway (377244); GABAergic Synapse Pathway (377129); Glutamatergic Synapse Pathway (213815); Glutamatergic Synapse Pathway (213811)

ncbi summary :

voltage-gated calcium channel that may be involved in secretion coupling in pancreatic beta cells [RGD, Feb 2006]

uniprot summary :

Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA). Subunit structure: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interact (via C-terminal CDB motif) with CABP1 in the pre- and postsynaptic membranes. Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Brain specific. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. Also found in heart, in kidney distal convoluted tubule (DCT), and in pituitary. Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. Sequence similarities: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily. [View classification]

size1 :

0.1 mg

price1 :

315 USD

more info or order :

MyBioSource product webpage