catalog number :
MBS390133
products full name :
Human C-Reactive Protein (CRP)
products short name :
[C-Reactive Protein (CRP)]
products name syn :
[Human C-Reactive Protein (CRP).]
other names :
[C-reactive protein; C-reactive protein; C-reactive protein; C-reactive protein, pentraxin-related, gene 4 a; C-reactive protein, pentraxin-related, gene 4]
products gene name :
[CRP]
other gene names :
[crp.4-a; crp; CRP; ptx1; crp.4a; CRP]
uniprot entry name :
CRP_XENLA
host :
Human pleural fluid
purity :
> 99 % by SDS-PAGE.
concentration :
1mg / ml, determined by the Lowry method.
storage stability :
4 degree C for short-term storage and -20 degree C for long-term storage.
tested application :
SDS-PAGE
image1 heading :
Testing Data)
other info2 :
Preservative: 50 mM Tris-HCl, 250 mM NaCl, 5 mM CaCl 2 , 0.1% NaN 3 , pH 8.0. Centrifuge before use!
products categories :
Human Aplipoproteins
products description :
Human C-reactive protein (CRP) is an acute phase protein produced by the liver. It is a member of the pentraxin family of proteins with five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa). Among other markers of inflammation, CRP has been showed the strongest association with cardiovascular events. Clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. It is an important biomarker for detecting individuals at high risk of plaque rapture.
uniprot summary :
Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine. Cofactor: Binds 2 calcium ions per subunit . By similarity. Subunit structure: Homodimer; disulfide-linked. It is not known if it assembles into a pentaxin (or pentraxin) structure. Pentaxins have a discoid arrangement of 5 non-covalently bound subunits. Subcellular location: Secreted. Developmental stage: Is initially detected at the late tail bud stage when the liver appears. Ref.1. Post-translational modification: Cys-89 or Cys-223 or Cys-236 could be involved in interchain disulfide linkage. Sequence similarities: Belongs to the pentaxin family.Contains 1 pentaxin domain.