catalog number :
MBS390021
products full name :
Biotinylated Goat Anti-Human Apolipoprotein CII
products short name :
Apolipoprotein CII
products name syn :
Biotinylated Sheep Anti-Human Apolipoprotein CII (apoCII),Polyclonal Antibody
other names :
apolipoprotein C-II; Apolipoprotein C-II; apolipoprotein C-II; apolipoprotein C2; apolipoprotein C-II; Apolipoprotein C2
products gene name :
Apo CII
other gene names :
APOC2; APOC2; APO-CII; APOC-II; APC2; Apo-CII; ApoC-II
uniprot entry name :
APOC2_HUMAN
specificity :
Specifically binds to human apoCII. Dilution for immunoblot and ELISA range: 200 to 5,000
concentration :
1.2 mg / ml
storage stability :
-20 degree C for long-term storage, 2-8 degree C for short-term storage. Aliquot to avoid repeated thaw and freeze.
tested application :
ELISA (EIA), Immunoblot (IB)
app notes :
Freeze-dried powder. Dilution for Immunoblot & ELISA range: 1,000 to 5,000. Use: The antibody can be used for detection of apoCII in human plasma and lipoproteins, immunoassays and immunoblots.
other info1 :
Source Note: Polyclonal antibody purified by human apolipoprotein
other info2 :
Preservative: 10 mM PBS, 0.14 M NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2.
products categories :
Biotin Antibodies
ncbi acc num :
NP_000474.2
ncbi gb acc num :
NM_000483.4
ncbi mol weight :
11,284 Da
ncbi pathways :
Chylomicron-mediated Lipid Transport Pathway 106157!!Disease Pathway 530764!!Diseases Associated With Visual Transduction Pathway 771581!!HDL-mediated Lipid Transport Pathway 106158!!Lipid Digestion, Mobilization, And Transport Pathway 106111!!Lipoprotein Metabolism Pathway 106156!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Retinoid Metabolism And Transport Pathway 187208!!Signal Transduction Pathway 477114
ncbi summary :
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
uniprot summary :
Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Subcellular location: Secreted. Tissue specificity: Secreted in plasma. Involvement in disease: Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23. Sequence similarities: Belongs to the apolipoprotein C2 family.