Human High Mobility Group Protein B1 (HMGB-1) ELISA Kit | MyBioSource MBS3800615 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human High Mobility Group Protein B1 (HMGB-1) ELISA Kit

catalog :

MBS3800615

quantity :

48-Strip-Wells

price :

310 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS3800615

products type :

ELISA Kit

products full name :

Human High Mobility Group Protein B1 (HMGB-1) ELISA Kit

products short name :

[High Mobility Group Protein B1 (HMGB-1)]

other names :

[high mobility group protein B1 isoform 1; High mobility group protein B1; high mobility group protein B1; high mobility group box 1; High mobility group protein 1]

products gene name :

[HMGB-1]

other gene names :

[HMGB1; HMGB1; HMG1; HMG3; HMG-1; SBP-1; HMG1; HMG-1]

uniprot entry name :

HMGB1_HUMAN

reactivity :

Human

sequence length :

215

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, plasma, cell culture supernate and other biological fluids. Assay Type: Sandwich. Detection Range: 1250 pg/ml-20000 pg/ml. Sensitivity: 10 pg/ml

products description :

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofHMGB-1in the sample, This HMGB-1ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusHMGB-1concentration. The concentration ofHMGB-1in the samples is then determined by comparing the O.D. of the samples to the standard curve.

ncbi gi num :

4504425

ncbi gb acc num :

NP_002119.1

uniprot acc num :

P09429

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Activation Of DNA Fragmentation Factor Pathway (105683); Advanced Glycosylation Endproduct Receptor Signaling Pathway (187092); Apoptosis Pathway (105648); Apoptosis Induced DNA Fragmentation Pathway (105682); Apoptotic Execution Phase Pathway (105677); Base Excision Repair Pathway (83043); Base Excision Repair Pathway (451); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); DAI Mediated Induction Of Type I IFNs Pathway (576256)

ncbi summary :

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

uniprot summary :

HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family. Protein type: DNA repair, damage; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 13q12. Cellular Component: nucleoplasm; extracellular space; cell surface; transcriptional repressor complex; extracellular region; condensed chromosome; nucleus. Molecular Function: protein binding; RAGE receptor binding; double-stranded DNA binding; damaged DNA binding; cytokine activity; chromatin binding; transcription factor activity; DNA bending activity; transcription factor binding; single-stranded DNA binding; chemoattractant activity. Biological Process: negative regulation of transcriptional preinitiation complex assembly; DNA topological change; V(D)J recombination; apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; base-excision repair, DNA ligation; negative regulation of transcription from RNA polymerase II promoter; DNA recombination; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; myeloid dendritic cell activation; inflammatory response to antigenic stimulus; positive chemotaxis; dendritic cell chemotaxis; innate immune response; DNA ligation during DNA repair; positive regulation of transcription from RNA polymerase II promoter; DNA fragmentation during apoptosis; neurite development; cell structure disassembly during apoptosis; positive regulation of DNA binding

size1 :

48-Strip-Wells

price1 :

310 USD

size2 :

96-Strip-Wells

price2 :

335

size3 :

5x96-Strip-Wells

price3 :

1515

size4 :

10x96-Strip-Wells

price4 :

2880

more info or order :

MyBioSource product webpage