product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit Anti-Nesprin 2
catalog :
MBS375177
quantity :
0.1 mL
price :
415 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS375177
products type :
Antibody
products full name :
Rabbit Anti-Nesprin 2
products short name :
Nesprin 2
products name syn :
DKFZP434H2235 antibody; DKFZp686E01115 antibody; DKFZp686H1931 antibody; FLJ11014 antibody; FLJ43727 antibody; FLJ45710 antibody; FLJ46790 antibody; KIAA1011 antibody; Nesprin2 antibody; NUA antibody; NUANCE antibody; Nuclear envelope spectrin repeat protein 2 antibody; Nucleus and actin connecting element antibody; Nucleus and actin connecting element protein antibody; Protein NUANCE antibody; Spectrin repeat containing nuclear envelope 2 antibody; Synaptic nuclear envelope protein 2 antibody; Synaptic nuclei expressed gene 2 antibody; SYNE 2 antibody; SYNE2 antibody
other names :
nesprin-2 isoform 2; Nesprin-2; nesprin-2; nesprin 2; nuclear envelope spectrin repeat protein 2; nucleus and actin connecting element protein; polytrophin; synaptic nuclear envelope protein 2; synaptic nuclei expressed gene 2; spectrin repeat containing, nuclear envelope 2; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein; Protein NUANCE; Synaptic nuclear envelope protein 2; Syne-2
other gene names :
SYNE2; SYNE2; NUA; EDMD5; Nesp2; TROPH; NUANCE; SYNE-2; Nesprin-2; KIAA1011; NUA; Protein NUANCE; Syne-2
uniprot entry name :
SYNE2_HUMAN
host :
Rabbit
reactivity :
Mouse
sequence length :
429
specificity :
Mouse nesprin2
form :
Serum containing 0.1% sodium azide
storage stability :
Store at 4 degree C for one month, or in small aliquots at -20 degree C for longer periods. Store in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.
tested application :
Western Blot (WB), Immunoprecipitation (IP), Immunofluoresence (IF)
app notes :
Optimal antibody dilution should be determined by titration, however as a guideline try between 1:500-1:2000
other info1 :
Target Antigen: Nesprin 2. Immunogen: GST-Nesprin 2 peptide
ncbi gi num :
33624861
ncbi acc num :
NP_878914.1
ncbi gb acc num :
NM_182910.2
uniprot acc num :
Q8WXH0
ncbi mol weight :
119,457 Da
ncbi pathways :
Cell Cycle Pathway (530733); Meiosis Pathway (477133); Meiotic Synapsis Pathway (477134); Ovarian Infertility Genes Pathway (198801)
ncbi summary :
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
uniprot summary :
SYNE2: a nuclear transmembrane protein involved in the maintenance of nuclear organization and structural integrity. The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells. Probable anchoring protein which theters the nucleus to the cytoskeleton. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Nine alternatively spliced isoforms have been described. Protein type: Membrane protein, integral; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 14q23.2. Cellular Component: nucleoplasm; filopodium membrane; nuclear outer membrane; intermediate filament cytoskeleton; nuclear membrane; sarcoplasmic reticulum membrane; nuclear lumen; focal adhesion; sarcoplasmic reticulum; mitochondrion; cytoplasm; integral to membrane; nuclear envelope; nucleus; Z disc. Molecular Function: actin filament binding; protein binding; actin binding. Biological Process: centrosome localization; establishment and/or maintenance of cell polarity; nuclear migration along microfilament; nuclear migration; nuclear membrane organization and biogenesis; positive regulation of cell migration. Disease: Emery-dreifuss Muscular Dystrophy 5, Autosomal Dominant
size1 :
0.1 mL
price1 :
415 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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