Rat Anti-EpCAM [G8.8] | MyBioSource MBS375137 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rat Anti-EpCAM [G8.8]

catalog :

MBS375137

quantity :

0.1 mL

price :

415 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

[G8.8]

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS375137

products type :

Antibody

products full name :

Rat Anti-EpCAM [G8.8]

products short name :

[EpCAM]

products name syn :

[17 1A antibody; 323/A3 antibody; Adenocarcinoma associated antigen antibody; Antigen identified bymonoclonal antibody AUA1 antibody; CD326 antibody; CD326 antigen antibody; Cell surface glycoprotein Trop 1antibody; CO 17A antibody; CO17 1A antibody; CO17A antibody; EGP antibody; EGP2 antibody; EGP40 antibody; EpCAM antibody; Epithelial cell surface antigen antibody; Epithelial cellular adhesion molecule antibody; Epithelialglycoprotein antibody; GA733 2 antibody; hEGP 2 antibody; KS 1/4 antigen antibody; KSA antibody; Lymphocyteantigen 74 antibody; M1S2 antibody; M4S1 antibody; Major gastrointestinal tumor associated protein GA733 2antibody; MIC18 antibody; MK 1 antibody; TACD1 antibody; TACSTD1 antibody; TROP1 antibody; Tumor associatedcalcium signal transducer 1 antibody]

other names :

[epithelial cell adhesion molecule; Epithelial cell adhesion molecule; epithelial cell adhesion molecule; adenocarcinoma-associated antigen; cell surface glycoprotein Trop-1; epithelial glycoprotein 314; human epithelial glycoprotein-2; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); tumor-associated calcium signal transducer 1; epithelial cell adhesion molecule; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD_antigen: CD326]

products gene name :

[EpCAM]

other gene names :

[EPCAM; EPCAM; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Ep-CAM; EGP; EGP314; hEGP314]

uniprot entry name :

EPCAM_HUMAN

clonality :

Monoclonal

isotype :

IgG2a kappa

clone :

[G8.8]

host :

Rat

reactivity :

Mouse

sequence length :

314

specificity :

Mouse Ep-CAM; CD326 on mouse material

purity :

Protein G

form :

Purified antibody containing PBS +0.1% sodium azide

concentration :

1mg/ml

storage stability :

Store at 4 degree C for one month, or in small aliquots at -20 degree C for longer periods. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.

tested application :

Immunohistochemistry (IHC). Immunoprecipitation (IP). Western Blot (WB) not tested

app notes :

Optimal antibody dilution should be determined by titration, however as a guideline try at 0.5ug/ml for IHC on mouse material

other info1 :

Target Antigen: EpCAM. Immunogen: Thymic epithelial cell line

other info2 :

Myeloma/fusion Partners: X63Ag8.653. Research Areas: Immunology. Technical Notes: Ep-CAM is widely expressed among epithelia; not restricted to thymus. Health and Safety: Products that contain sodium azide (a poisonous and hazardous substance) should be handled by trained staff only.

products references :

Farr A et al. Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium. J Histochem Cytochem 39:645-53 (1991) PUBMED

ncbi gi num :

218505670

ncbi acc num :

NP_002345.2

ncbi gb acc num :

NM_002354.2

uniprot acc num :

P16422

ncbi mol weight :

34,932 Da

ncbi summary :

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]

uniprot summary :

EPCAM: a single-pass type I membrane protein of the EPCAM family. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas including pancreatic carcinoma. May be a marker of cancer stem cells. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2p21. Cellular Component: cell surface; tight junction; basolateral plasma membrane; apical plasma membrane; integral to membrane; plasma membrane; lateral plasma membrane. Molecular Function: protein binding; protein complex binding. Biological Process: ureteric bud development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation. Disease: Diarrhea 5, With Tufting Enteropathy, Congenital; Colorectal Cancer, Hereditary Nonpolyposis, Type 8

size1 :

0.1 mL

price1 :

415 USD

more info or order :

MyBioSource product webpage