catalog number :
MBS375097
products full name :
Mouse Anti-PP2A alpha (methyl L309) [2A10]
products short name :
[PP2A alpha]
products name syn :
[PP2A alpha antibody; PP2A C antibody; PP2A-alpha antibody; PP2AA_HUMAN antibody; PP2Ac antibody; PP2CA antibody; PPP2CA antibody; Protein phosphatase 2, catalytic subunit, alpha isoform antibody; Replication protein C antibody]
products gene name :
[PP2A alpha]
reactivity :
Mouse, Human, Saccharomyces cerevisiae
specificity :
Alpha + beta isoforms of PP2A C
form :
Purified antibody (from supernatant) containing PBS + 0.1% sodium azide
storage stability :
Store at 4 degree C for one month, or in small aliquots at -20 degree C for longer periods. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.
tested application :
Western Blot (WB), Immunoprecipitation (IP)
app notes :
Optimal antibody dilution should be determined by titration, however as a guideline start at 1:500 for Wester Blot.
other info1 :
Target Antigen: PP2A alpha (methyl L309) . Immunogen: C-terminal peptide (Methyl-Leu309) of human PP2A catalic subunit.
other info2 :
Myeloma/fusion Partners: X63-Ag8.653. Health & Safty: Products that contain sodium azide (a poisonous and hazardous substance) should be handled by trained staffs only.
products references :
Benziane B et al. Activation of AMP-activated Protein Kinase Stimulates Na+,K+-ATPase Activity in Skeletal Muscle Cells. J Biol Chem 287:23451-63 (2012). WB PUBMED Li T et al. Microcystin-LR (MCLR) Induces a Compensation of PP2A Activity Mediated by a4 Protein in HEK293 Cells. Int J Biol Sci 7:740-52 (2011). WB ; Human PUBMED Finnegan S et al. A stress survival response in retinal cells mediated through inhibition of the serine / threonine phosphatase PP2A. Eur J Neurosci : (2010). WB ; Mouse PUBMED Hombauer H et al. Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. PLoS Biol 5:e155 (2007) PUBMED Sontag E et al. Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 63:1080-91 (2004) PUBMED Sontag E et al. Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. J Neuropathol Exp Neurol 63:287-301 (2004) PUBMED Fellner T et al. A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. Genes Dev 17:2138-50 (2003) PUBMED