product summary
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company name :
MyBioSource
product type :
antibody
product name :
Goat Anti-Emerin
catalog :
MBS375073
quantity :
0.05 mL
price :
415 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
clone name :
[AGP10 antisera]
reactivity :
human
more info or order :
image
image 1 :
Staining of nuclear envelope using Anti-Emerin in mouse myoblast C2C12 cells
product information
catalog number :
MBS375073
products type :
Antibody
products full name :
Goat Anti-Emerin
products short name :
[Emerin]
products name syn :
[EDMD antibody; EMD antibody; Emery Dreifuss muscular dystrophy antibody; STAantibody]
other names :
[emerin; Emerin; emerin; LEM domain containing 5; emerin]
other gene names :
[EMD; EMD; STA; EDMD; LEMD5; EDMD; STA]
uniprot entry name :
EMD_HUMAN
clonality :
polyclonal
clone :
[AGP10 antisera]
host :
goat
sequence length :
254
specificity :
Human & rodent.
purity :
Affinity purified on Ni-affinity column with attached antigen
form :
Purified antiserum in (PBS + 10% gelatin) 0.1% sodium azide
storage stability :
Store at 4°C for one month, or in small aliquots at -20°C for longer periods. Storage in frost-freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.
tested application :
Immunoblotting & Immunofluorescence (paraformaldehyde, methanol & acetone).
app notes :
Guideline try 1:1000 for Immunoblotting & 1:100 for Immunofluorescence.
image1 heading :
Testing Data(TD)
other info1 :
Target Antigen: Emerin. Immunogen: Human emerin residues 170 (His tag at C-terminus)
other info2 :
Note: Product that contains sodium azide (a poisonous and hazardous substance)should be handled by trained staff only.
ncbi gi num :
4557553
ncbi acc num :
NP_000108.1
ncbi gb acc num :
NM_000117.2
uniprot acc num :
P50402
ncbi pathways :
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Clearance Of Nuclear Envelope Membranes From Chromatin Pathway (771572); Depolymerisation Of The Nuclear Lamina Pathway (1127548); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229)
ncbi summary :
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]
uniprot summary :
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
size1 :
0.05 mL
price1 :
415 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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