Mouse Anti-Mer Receptor Tyrosine Kinase (MERTK) | MyBioSource MBS375035 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti-Mer Receptor Tyrosine Kinase (MERTK)

catalog :

MBS375035

quantity :

0.05 mL

price :

370 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[A311F9G3]

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS375035

products type :

Antibody

products full name :

Mouse Anti-Mer Receptor Tyrosine Kinase (MERTK)

products short name :

[MERTK]

products name syn :

[c MER antibody; c mer proto oncogene tyrosine kinase antibody; cMER antibody; cmer protooncogene tyrosine kinase antibody]

other names :

[MERTK protein; Tyrosine-protein kinase Mer; tyrosine-protein kinase Mer; MER receptor tyrosine kinase; STK kinase; c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; receptor tyrosine kinase MerTK; MER proto-oncogene, tyrosine kinase; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK]

products gene name :

[MERTK]

other gene names :

[MERTK; MERTK; MER; RP38; c-Eyk; c-mer; Tyro12; MER]

uniprot entry name :

MERTK_HUMAN

clonality :

Monoclonal

isotype :

IgG1 kappa light chain

clone :

[A311F9G3]

host :

Mouse

sequence length :

823

specificity :

Human Mer

purity :

Protein G

form :

Purified antibody in PBS + 0.1% sodium azide

concentration :

1mg/ml

storage stability :

Store at 4 degree C for one month, or in small aliquots at -20 degree C for longer periods. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.

tested application :

Western Blot (WB)

app notes :

Optimal antibody dilution should be determined by titration, however as a guideline use at WB: 1:1000.

image1 heading :

Testing Data

other info1 :

Target Antigen: MERTK. Immunogen: Human MERTK extracellular domain.

other info2 :

Myeloma/fusion Partners: FOX NY mouse myeloma

products references :

Zahuczky G et al. Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of mertk in enhanced phagocytosis. PLoS One 6:e21349 (2011). WB ; Human PUBMED Graham DK et al. Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. Clin Cancer Res 12:2662-9 (2006) PUBMED Graham DK et al. Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ 5:647-57 (1994) PUBMED

ncbi gi num :

109732052

ncbi acc num :

AAI14918.1

uniprot acc num :

Q12866

ncbi mol weight :

110,249 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (106062); Hemostasis Pathway (106028)

ncbi summary :

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

uniprot summary :

Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Protein type: EC 2.7.10.1; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; TK group; Axl family. Chromosomal Location of Human Ortholog: 2q14.1. Cellular Component: extracellular space; photoreceptor outer segment; integral to plasma membrane; cytoplasm; plasma membrane. Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding. Biological Process: negative regulation of lymphocyte activation; platelet activation; peptidyl-tyrosine phosphorylation; vagina development; protein amino acid phosphorylation; phagocytosis; cell surface receptor linked signal transduction; cell-cell signaling; retina development in camera-type eye; natural killer cell differentiation; positive regulation of phagocytosis; protein kinase B signaling cascade; spermatogenesis; blood coagulation; leukocyte migration; apoptotic cell clearance; secretion by cell. Disease: Retinitis Pigmentosa 38

size1 :

0.05 mL

price1 :

370 USD

size2 :

0.1 mL

price2 :

415

more info or order :

MyBioSource product webpage