antibody

Gastrin

MBS373014

3 ml

170 USD

polyclonal

rabbit

nonconjugated

Antibody

Gastrin

Gastrin

Gastrin; Gastrin; gastrin; OTTHUMP00000164741; gastrin; Gastrin component IGastrin-52; G52Big gastrin; Alternative name(s):; Gastrin component II; Gastrin-34; G34Gastrin; Alternative name(s):; Gastrin component III; Gastrin-17

GAST; GAST; GAS; GAS

GAST_HUMAN

Polyclonal

IgG

polyclonal

Rabbit

Gastrin is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Store at 2 to 8 degree C in the dark.

Control: Stomach. Localization: Cytoplasmic

Reactivity Note: Paraffin, Frozen

Gastrin is a linear peptide hormone produced by G-cells of the duodenum and in the pyloric antrum of the stomach. It is secreted into the bloodstream. Gastrin antibody gives positive staining of G-cells of human antral/pyloric mucosa and cells producing gastrin or a structural gastrin analogue as is seen in the stomach. No staining of other cells or tissue types has been observed. This antibody may react with sulfated and non-sulfated forms of gastrin. The antibody cross-reacts with more than 50% of the present choleocystokinin octapeptide.

120952

P01350.1

P01350

P01350

11,394 Da

G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548!!Gastric Acid Secretion Pathway 154409!!Gastric Acid Secretion Pathway 154383!!Signaling By GPCR Pathway 106356

Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq]

Function: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Subcellular location: Secreted. Post-translational modification: Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Ref.12 Ref.13 Ref.14Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. Ref.12 Ref.13 Ref.14. Sequence similarities: Belongs to the gastrin/cholecystokinin family.

3 ml

170 USD