product summary
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company name :
MyBioSource
product type :
antibody
product name :
A-1-Antichymotrypsin
catalog :
MBS373003
quantity :
5 + Control Slides
price :
115 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS373003
products type :
Antibody
products full name :
A-1-Antichymotrypsin
products short name :
A-1-Antichymotrypsin
other names :
alpha-1-antichymotrypsin; Alpha-1-antichymotrypsin; alpha-1-antichymotrypsin; serpin A3; OTTHUMP00000028439; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Cell growth-inhibiting gene 24/25 protein; Serpin A3
other gene names :
SERPINA3; SERPINA3; ACT; AACT; GIG24; GIG25; MGC88254; AACT
uniprot entry name :
AACT_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
storage stability :
Store at 2 to 8 degree C in the dark.
ncbi gi num :
50659080
ncbi acc num :
NP_001076.2
ncbi gb acc num :
NM_001085.4
uniprot acc num :
P01011
ncbi mol weight :
47,651 Da
ncbi pathways :
Selenium Pathway (198825)
ncbi summary :
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq]
uniprot summary :
Function: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Ref.14. Subunit structure: Interacts with DNAJC1. Ref.18. Subcellular location: Secreted. Tissue specificity: Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. Ref.7 Ref.8. Domain: The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable. Miscellaneous: Alpha-1-antichymotrypsin can bind DNA. Sequence similarities: Belongs to the serpin family. Caution: It is uncertain whether Met-1 or Met-4 is the initiator. Sequence caution: The sequence AAA51543.1 differs from that shown. Reason: Frameshift at positions 101, 106, 111, 117, 123, 129 and 421. The sequence AAT08029.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAT08029.1 differs from that shown. Reason: Frameshift at position 4. The sequence BAD92297.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA48671.1 differs from that shown. Reason: Erroneous initiation.
size1 :
5 + Control Slides
price1 :
115 USD
size2 :
3 ml (Prediluted)
price2 :
125
size3 :
0.1 mL (Concentrate)
price3 :
155
size4 :
7 ml (Prediluted)
price4 :
165
size5 :
0.5 mL (Concentrate)
price5 :
185
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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