antibody

Adipophilin / ADRP

MBS370288

5 Control Slides

130 USD

monoclonal

mouse

nonconjugated

human, cow

immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

Antibody

Adipophilin / ADRP

[Adipophilin / ADRP]

[adipophilin; Perilipin-2; perilipin-2; Adipophilin; Adipose differentiation-related protein; ADRP]

[ADRP]

[PLIN2; PLIN2; ADFP; ADFP; ADRP; ADRP]

PLIN2_BOVIN

Monoclonal

IgG1

Mouse

Human

450

Adipophilin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Store at 2 to 8 degree C. Do not use after expiration date listed on package label. Termperature fluctuations should be avoided. Store appropriately when not in use, and avoid prolonged exposure to room temperature conditions.

Immunohistochemistry (IHC) Frozen/Paraffin

Dilution Information

Immunohistochemistry (IHC)

Localization: Membranous. Control: Adrenal, SCC, TCC Sebaceous Neoplasms

Intended Use: This antibody is intended for use in Immunohistochemical applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Nterpretation of results should be performed by a qualified medical professional. Immunogen: Synthetic peptide corresponding to the C-terminus of human Adipophilin.

Adipose differentiation-related protein, also known as perilipin 2 (PLIN2), ADRP or adipophilin, is a protein which in humans is encoded by the ADFP gene. Adipocyte differentiation-related protein is associated with the globule surface membrane material. This protein is a major constituent of the globule surface. Increase in mRNA levels is one of the earliest indications of adipocyte differentiation. Adipophilin occurs in a wide range of cultured cell lines, including fibroblasts and endothelial and epithelial cells. In tissues, however, expression of adipophilin is restricted to certain cell types, such as lactating mammary epithelial cells, adrenal cortex cells, Sertoli and Leydig cells of the male reproductive system, and steatosis or fatty change hepatocytes in alcoholic liver cirrhosis. Adipophilin expression in various sebaceous lesions and other cutaneous tumors with a clear cell histology that may mimic sebaceous differentiation. Adipophilin can be valuable in an immunohistochemical panel when evaluating cutaneous lesions with clear cell histology as it identifies intracytoplasmic lipid vesicles in sebaceous and xanthomatous lesions. In periocular lesions, it is effective in helping to exclude basal cell carcinoma and squamous cell carcinoma when sebaceous carcinoma is under consideration. Adipophilin expression is not as useful for the differential diagnosis that includes metastatic renal cell carcinoma, a rare but important, diagnostic differential. The pattern of adipophilin reactivity is important to observe as membranous vesicular staining is suggestive of intracellular lipids whereas granular cytoplasmic reactivity is not. Adipophilin is suitable for immunostaining and is helpful in the identification of intracytoplasmic lipids, as seen in sebaceous lesions. It is especially helpful in identifying intracytoplasmic lipid vesicles in poorly differentiated sebaceous carcinomas in challenging cases such as small periocular biopsy specimens.

5823591

CAB53860.1

Q9TUM6

49,102 Da

Adipogenesis Pathway (920913)

May be involved in development and maintenance of adipose tissue.

5 Control Slides

130 USD

0.1 mL (Concentrate)

165

3 ml (Prediluted)

190

0.5 mL (Concentrate)

365

7 mL (Prediluted)

365

1 mL (Concentrate)

620

15 mL (Prediluted)

675