product summary
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company name :
MyBioSource
product type :
antibody
product name :
MUC6
catalog :
MBS370148
quantity :
5 + Control Slides
price :
115 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CLH5
reactivity :
human
more info or order :
product information
catalog number :
MBS370148
products type :
Antibody
products full name :
MUC6
products short name :
MUC6
other names :
mucin-6; Mucin-6; mucin-6; gastric mucin-6; mucin 6, gastric; OTTHUMP00000228589; mucin 6, oligomeric mucus/gel-forming; Gastric mucin-6
products gene name :
MUC6
other gene names :
MUC6; MUC6; MUC-6
uniprot entry name :
MUC6_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
CLH5
host :
Mouse
reactivity :
Human
form :
Anti-MUC6 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
storage stability :
Store at 2 to 8 degree C in the dark.
other info1 :
Control: Stomach. Localization: Cytoplasmic
other info2 :
Reactivity Note: Paraffin, Frozen
products description :
Mucin 6, also known as MUC6, is a human gene. Mucin is a high M.W. (>1,000 kDa) glycoprotein, expressed by mucous cells of the gastric epithelium and by goblet cells of the fetal, precancerous and cancerous colon, but not by those of the normal colon. It also appears in other epithelial tissues, which are embryologically derived from the foregut (epigastric and bronchial epithelium) and in Muller ducts (mucous cells of the endocervix and urethral epithelium near the prostatic utriculus).
ncbi gi num :
151301154
ncbi acc num :
NP_005952.2
ncbi gb acc num :
NM_005961.2
uniprot acc num :
Q6W4X9
ncbi mol weight :
257,051 Da
ncbi pathways :
Metabolism Of Proteins Pathway (106230); O-linked Glycosylation Of Mucins Pathway (530747); Post-translational Protein Modification Pathway (161012); Termination Of O-glycan Biosynthesis Pathway (530748)
ncbi summary :
The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM]
uniprot summary :
Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Ref.10 Ref.11 Ref.12. Subunit structure: Multimer; disulfide-linked. Ref.8. Subcellular location: Secreted. Tissue specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13. Developmental stage: Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation. Ref.10 Ref.11. Induction: Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors. Ref.14. Post-translational modification: O-glycosylated. Ref.12. Polymorphism: The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical. Sequence similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 TIL (trypsin inhibitory-like) domain.Contains 3 VWFD domains. Sequence caution: The sequence AK092533 differs from that shown. Reason: Erroneous termination at position 2357. Translated as Glu.The sequence BAC04860.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
size1 :
5 + Control Slides
price1 :
115 USD
size2 :
3 ml (Prediluted)
price2 :
165
size3 :
0.1 mL (Concentrate)
price3 :
170
size4 :
7 ml (Prediluted)
price4 :
240
size5 :
0.5 mL (Concentrate)
price5 :
315
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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