MyBioSource

antibody

CD44

MBS370141

3 ml

200 USD

monoclonal

mouse

human

MBS370141

Antibody

CD44

CD44

CD44; CD44 antigen (Indian blood group), isoform CRA_g; CD44 antigen; epican; Hermes antigen; OTTHUMP00000232487; OTTHUMP00000232488; OTTHUMP00000232489; OTTHUMP00000232491; OTTHUMP00000232492; OTTHUMP00000232493; OTTHUMP00000232494; OTTHUMP00000232495; OTTHUMP00000232522; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system; CD44 molecule (Indian blood group); N/A

CD44

CD44; CD44; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; MGC10468; N/A

O95370_HUMAN

Monoclonal

IgG2a

MRQ-13

Mouse

CD44 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Store at 2 to 8 degree C in the dark.

Control: Tonsil, Kidney, Esophageal CA. Localization: Membranous

Reactivity Note: Paraffin, Frozen

The CD44 protein is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. CD44 is also known as Homing-cell adhesion molecule (H-CAM) and Phagocytic glycoprotein-1 (PgP-1). A specialized sialofucosylated glycoform of CD44 called HCELL is found natively on human hematopoietic stem cells and functions as a "bone-homing receptor", directing migration of human hematopoietic stem cells and mesenchymal stem cells to bone marrow. This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms; however, the full-length nature of some of these variants has not been determined. Splice variants of CD44 on Colon Cancer cells display the HCELL glycoform, which mediates binding to vascular E-selectin under hemodynamic flow conditions, a critical step in Colon Cancer metastasis. In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells and have been seen as an indicator of increased survival time in Epithelial Ovarian Cancer patients.

685122

O95370

15,635 Da

Cytokine Signaling In Immune System Pathway 366171!!ECM-receptor Interaction Pathway 83068!!ECM-receptor Interaction Pathway 479!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!Immune System Pathway 106386!!Interferon Signaling Pathway 187103!!Interferon Gamma Signaling Pathway 187106!!Osteopontin-mediated Events Pathway 137960!!Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway 137971

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq]

3 ml

200 USD