catalog number :
MBS370137
products full name :
MSH6
products short name :
MSH6
other names :
Msh6; CG7003 gene product from transcript CG7003-RA; Msh6; CG7003-PA; Msh6-PA
products gene name :
MSH6
other gene names :
Msh6; CG7003; DmelCG7003
form :
MSH6 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
storage stability :
Store at 2 to 8 degree C in the dark.
other info1 :
Control: Colon Mucosa, Colon Carcinoma. Localization: Nuclear
other info2 :
Reactivity Note: Paraffin, Frozen
products description :
MSH6 is a gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset Colorectal Carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited Colorectal Cancer in the western world. MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). The anti-MSH6 antibody is useful in screening patients and families for HNPCC. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite-stable counterparts.
ncbi acc num :
NP_648755.1
ncbi gb acc num :
NM_140498.1
ncbi pathways :
Mismatch Repair Pathway 3080!!Mismatch Repair Pathway 453