product summary
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company name :
MyBioSource
product type :
antibody
product name :
PD-1/CD279
catalog :
MBS370123
quantity :
5 + Control Slides
price :
115 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
NAT-105(MRQ-22)
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS370123
products type :
Antibody
products full name :
PD-1/CD279
products short name :
PD-1
products gene name :
PD-1
clonality :
Monoclonal
isotype :
IgG1
clone :
NAT-105(MRQ-22)
host :
Mouse
reactivity :
Human
form :
PD-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
storage stability :
Store at 2-8degree C. Do not use after expiration date listed on package label. Temperature fluctuations should be avoided. Store appropriately when not in use, and avoid prolonged exposure to room temperature conditions.
app notes :
Concentrated: 1:100-1:500 (volume) 1.0ml
other info1 :
Control: Tonsil, Lymph Node. Localization: Cytoplasmic
other info2 :
Reactivity Note: Paraffin, Frozen. Preservative: The sodium azide (NaN3) used as a preservative, is toxic if ingested.
products description :
Programmed Death 1 (PD-1 or CD279) is a Type I membrane protein comprised of 268 amino acids. PD-1 is a member of the extended CD28/CTLA-4 family of T-cell regulators. PD-1 is expressed on the surface of activated T-cells, B-cells, and macrophages. In comparison to CTLA-4, PD-1 more broadly negatively regulates immune responses. New data suggests that expression of PD-L1 on tumor cells inhibits anti-tumor activity through engagement f PD-1 on effector T-cells. Expression of PD-L1 on tumors is correlated with reduced survival in esophageal, pancreatic and other types of cancers, highlighting the relevance of exploring the PD-1 pathway as a target for immunotherapy. Studies have found that PD-1 is expressed on most T-cells and a small subset of B-cells in the light zone of germinal centers, but not elsewhere in the tonsil. On that basis, it was postulated that PD-1 may play a role in the process of clonal selection of centrocytes, which occurs in this subanatomic site in germinal centers. PD-1 is a new marker of Angioimmunoblastic Lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and bcl-6, PD-1 is expressed by few B-cells, so it may be a more specific and useful diagnostic marker in Angioimmunoblastic Lymphoma. It also seems to stain a greater percentage of CD3-positive neoplastic cells in Angioimmunoblastic Lymphoma than either CD10 or bcl-6.
size1 :
5 + Control Slides
price1 :
115 USD
size2 :
3 ml (Prediluted)
price2 :
145
size3 :
0.1 mL (Concentrate)
price3 :
185
size4 :
7 ml (Prediluted)
price4 :
205
size5 :
15 ml (Prediluted)
price5 :
290
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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