VEGF | MyBioSource MBS370114 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

VEGF

catalog :

MBS370114

quantity :

3 ml

price :

320 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

RBT-VEGF

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS370114

products type :

Antibody

products full name :

VEGF

products short name :

VEGF

other names :

vascular endothelial growth factor; Vascular endothelial growth factor A; vascular endothelial growth factor A; OTTHUMP00000016487; OTTHUMP00000016488; OTTHUMP00000165985; OTTHUMP00000165986; OTTHUMP00000165987; OTTHUMP00000224107; OTTHUMP00000224108; OTTHUMP00000224109; OTTHUMP00000224153; OTTHUMP00000224154; OTTHUMP00000224423; OTTHUMP00000224424; OTTHUMP00000224425; OTTHUMP00000224426; OTTHUMP00000224427; OTTHUMP00000224428; OTTHUMP00000224429; OTTHUMP00000224430; vascular permeability factor; vascular endothelial growth factor A; Vascular permeability factor

products gene name :

VEGF

other gene names :

VEGFA; VEGFA; VPF; VEGF; MVCD1; MGC70609; VEGF

uniprot entry name :

VEGFA_HUMAN

clonality :

Monoclonal

isotype :

IgG

clone :

RBT-VEGF

host :

Rabbit

storage stability :

Store at 2 to 8 degree C in the dark.

ncbi gi num :

220732299

ncbi acc num :

CAC19513.2

ncbi gb acc num :

AL136131.15

uniprot acc num :

P15692

ncbi mol weight :

27,042 Da

ncbi pathways :

Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Endochondral Ossification Pathway 198812!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!Formation Of Platelet Plug Pathway 106029!!Glypican 1 Network Pathway 138010!!HIF-1-alpha Transcription Factor Network Pathway 138045

ncbi summary :

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq]

uniprot summary :

Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Ref.27 Ref.30. Subunit structure: Homodimer; disulfide-linked. Also found as heterodimer with PGF. Subcellular location: Secreted. Note: VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin. Ref.26 Ref.28 Ref.32. Tissue specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. Induction: Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and oncogenic mutations. Involvement in disease: Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [. MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Sequence similarities: Belongs to the PDGF/VEGF growth factor family. Sequence caution: The sequence AAC63102.1 differs from that shown. Reason: Erroneous initiation. The sequence AAC63143.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.The sequence CAC19512.2 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.The sequence CAC19516.2 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.

size :

3 ml

price :

320 USD

more info or order :

MyBioSource product webpage