TTF-1 | MyBioSource MBS370112 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TTF-1

catalog :

MBS370112

quantity :

3 ml

price :

195 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8G7G3/1

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS370112

products type :

Antibody

products full name :

TTF-1

products short name :

TTF-1

other names :

homeobox protein Nkx-2.1 isoform 1; Homeobox protein Nkx-2.1; homeobox protein Nkx-2.1; NK-2 homolog A; OTTHUMP00000178847; OTTHUMP00000225297; thyroid nuclear factor 1; thyroid transcription factor 1; homeobox protein NK-2 homolog A; NK2 homeobox 1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1

products gene name :

TTF-1

other gene names :

NKX2-1; NKX2-1; BCH; BHC; NK-2; TEBP; TTF1; NKX2A; TITF1; TTF-1; NKX2.1; NKX2A; TITF1; TTF1

uniprot entry name :

NKX21_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

8G7G3/1

host :

Mouse

form :

TTF-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

storage stability :

Store at 2 to 8 degree C in the dark.

other info1 :

Control: Adenocarcinoma of Lung, Normal Lung, Thyroid. Localization: Nuclear

other info2 :

Reactivity Note: Paraffin, Frozen

products description :

Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific to the thyroid, lung and diencephalon. It is also known as thyroid-specific enhancer binding protein and NKX-2. It is used as a marker to determine if a tumor oringinates in the lung or thyroid. TTF-1 positive cells are found in Type II pneumocytes and Clara cells in the lung. In the thyroid, follicular and parafollicular cells are positive. TTF-1 is useful in differentiating primary Adenocarcinoma of the Lung from Metastatic Carcinomas of the breast and Malignant Mesothelioma. It can also be used to differentiate Small- Cell Lung Carcinoma from lymphoid infiltrates. For lung cancers, Adenocarcinomas are usually positive, while Squamous Cell Carcinomas and Large Cell Carcinomas are rarely positive. Small-Cell Carcinomas (of any primary site) are usually positive.

ncbi gi num :

118766339

ncbi acc num :

NP_001073136.1

ncbi gb acc num :

NM_001079668.1

uniprot acc num :

Q7KZF6

ncbi mol weight :

41606 Da

ncbi pathways :

FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911

ncbi summary :

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq]

uniprot summary :

Function: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Subunit structure: Interacts with WWTR1. Ref.10. Subcellular location: Nucleus. Tissue specificity: Thyroid and lung. Post-translational modification: Phosphorylated on serine residues. Involvement in disease: Defects in NKX2-1 are the cause of benign hereditary chorea (BHC) [. MIM:118700]; also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances. Ref.11 Ref.15Defects in NKX2-1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD) [. MIM:610978]. This syndrome include neurological, thyroid, and respiratory problems. Ref.12 Ref.13 Ref.14 Ref.15. Sequence similarities: Belongs to the NK-2 homeobox family.Contains 1 homeobox DNA-binding domain. Sequence caution: The sequence AAH06221.2 differs from that shown. Reason: Erroneous initiation. The sequence BAA23527.1 differs from that shown. Reason: Erroneous gene model prediction.

size :

3 ml

price :

195 USD

more info or order :

MyBioSource product webpage