Renal Cell Carcinoma | MyBioSource MBS370104 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Renal Cell Carcinoma

catalog :

MBS370104

quantity :

3 ml

price :

215 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PN-15

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS370104

products type :

Antibody

products full name :

Renal Cell Carcinoma

products short name :

Renal Cell Carcinoma

other names :

renal cell carcinoma associated antigen G250; Carbonic anhydrase 9; carbonic anhydrase 9; pMW1; CA-IX; P54/58N; membrane antigen MN; carbonic dehydratase; carbonate dehydratase IX; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250; carbonic anhydrase IX; Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1

other gene names :

CA9; CA9; MN; CAIX; G250; MN; CA-IX; CAIX

uniprot entry name :

CAH9_HUMAN

clonality :

Monoclonal

isotype :

IgG1/K

clone :

PN-15

host :

Mouse

form :

Anti-Renal Cell Carcinoma is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

storage stability :

Store at 2 to 8 degree C in the dark.

other info1 :

Control: Kidney, Renal Cell Carcinoma. Localization: Cytoplasmic, Membranous

other info2 :

Reactivity Note: Paraffin, Frozen

products description :

Renal Cell Carcinoma, also known as a Gurnistical Tumor, is the most common form of kidney cancer arising from the renal tubule. It is also the most common type of kidney cancer in adults. Initial treatment is surgery because it is notoriously resistant to radiation therapy and chemotherapy, although some cases respond to immunotherapy. Renal Cell Carcinoma antibody recognizes a 200 kDa glycoprotein localized in the brush border of the proximal renal tubule. This antibody immunoreacts with approximately 90% of Primary Renal Cell Carcinomas and approximately 85% of Metastatic Renal Cell Carcinomas. Other tumors that may react with this antibody are Parathyroid Adenoma, an occasional Breast Carcinoma. Nephroblastoma, Oncocytoma, Mesoblastic Nephroma, Transitional Cell Carcinoma, and Angiomyolipoma are not labeled with this antibody.

ncbi gi num :

7327888

ncbi acc num :

CAB82444.1

uniprot acc num :

Q16790

ncbi mol weight :

49,698 Da

ncbi pathways :

Cellular Response To Hypoxia Pathway 645259!!Cellular Responses To Stress Pathway 645258!!HIF-1-alpha Transcription Factor Network Pathway 138045!!Metabolism Pathway 477135!!Nitrogen Metabolism Pathway 83025!!Nitrogen Metabolism Pathway 416!!Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway 645263!!Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway 645260!!Reversible Hydration Of Carbon Dioxide Pathway 645352

ncbi summary :

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Ref.12. Catalytic activity: H2CO3 = CO2 + H2O. Cofactor: Zinc. Enzyme regulation: Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). Ref.10 Ref.11 Ref.14 Ref.15. Subunit structure: Forms oligomers linked by disulfide bonds. Ref.12 Ref.17. Subcellular location: Nucleus. Nucleus nucleolus. Cell membrane; Single-pass type I membrane protein. Cell projection microvillus membrane; Single-pass type I membrane protein. Note: Found on the surface microvilli and in the nucleus, particularly in nucleolus. Ref.8. Tissue specificity: Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. Induction: By hypoxia. Ref.10 Ref.11 Ref.12 Ref.14 Ref.15. Post-translational modification: Asn-346 bears high-mannose type glycan structures. Sequence similarities: Belongs to the alpha-carbonic anhydrase family. Biophysicochemical propertiespH dependence:Optimum pH is 6.5. Ref.17

size :

3 ml

price :

215 USD

more info or order :

MyBioSource product webpage