antibody

Inhibin, alpha

MBS370081

5 + Control Slides

115 USD

monoclonal

mouse

nonconjugated

R1

Antibody

Inhibin, alpha

Inhibin, alpha

inhibin alpha

Monoclonal

IgG2a

R1

Mouse

Human, Dog, Cat

Inhibin alpha is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Store at 2 to 8 degree C in the dark.

Control: Adrenal Cortex, Placenta, Testis, Corpus Luteum. Localization: Cytoplasmic

Reactivity Note: Paraffin, Frozen

Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex-cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits (A or B), while their alpha subunits are identical. Inhibin belongs to the transforming growth factor-beta (TGF-beta) family. Anti-Inhibin Alpha has demonstrated utility in differentiation between Adrenal Cortical Tumors and Renal Cell Carcinoma. Sex-Cord Stromal Tumors of the Ovary as well as Trophoblastic Tumors also demonstrate cytoplasmic positivity with this antibody.

208436014

Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)

This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion.[provided by RefSeq, Dec 2010]

INHA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2q35. Cellular Component: photoreceptor outer segment; photoreceptor inner segment; cell soma; extracellular region. Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding. Biological Process: hemoglobin biosynthetic process; negative regulation of B cell differentiation; nervous system development; regulation of cell cycle; male gonad development; signal transduction; negative regulation of interferon-gamma biosynthetic process; negative regulation of cell cycle; negative regulation of follicle-stimulating hormone secretion; regulation of cell proliferation; response to external stimulus; regulation of apoptosis; cell surface receptor linked signal transduction; cell-cell signaling; ovarian follicle development; negative regulation of macrophage differentiation; regulation of MAPKKK cascade; negative regulation of phosphorylation; erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; cell differentiation; cell cycle arrest; cell development; skeletal development

5 + Control Slides

115 USD

3 ml (Prediluted)

160

0.1 mL (Concentrate)

185

7 ml (Prediluted)

225

0.5 mL (Concentrate)

310