antibody

Follicular Dendritic Cell

MBS370070

5 + Control Slides

115 USD

monoclonal

mouse

nonconjugated

CNA.42

Antibody

Follicular Dendritic Cell

Follicular Dendritic Cell

follicular dendritic cell secreted peptide; Follicular dendritic cell secreted peptide; follicular dendritic cell secreted peptide; FDC secreted protein; follicular dendritic cell secreted protein

FDCSP; FDCSP; C4orf7; FDC-SP; C4orf7; FDC secreted protein; FDC-SP

FDSCP_HUMAN

Monoclonal

IgM/K

CNA.42

Mouse

Human

Anti-FDC is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Store at 2 to 8 degree C in the dark.

Control: Tonsil, Lymph Node. Localization: Cytoplasmic

Reactivity Note: Paraffin, Frozen

Follicular Dendritic Cells (FDC) are immune cells whose main function is to process antigen material and present it superficially to other cells of the immune system. Dendritic cells are present in small quantities in tissues that are in contact with the external environment, mainly the skin (where they are often called Langerhans cells) and the inner lining of the nose, lungs, stomach and intestines. They can also be found in an immature state in the blood. Once activated, they migrate to the lymphoid tissues where they interact with T-cells and B-cells to initiate and shape the immune response. Anti-FDC is useful in the identification of follicular dendritic cell matrix found in normal lymph nodes and tonsillar tissue. This antibody has been found to label cells in approximately 60% of Anaplastic Large-Cell Lymphomas, and approximately 45% of T-cell Lymphomas. This antibody also labels Follicular Dendritic Cell Tumors. Several normal non-lymphoid tissues are labeled with anti-FDC: pancreatic islet cells, gastric chief cells, myelin sheaths, salivary glands, Leydig cells of the testis, and endothelial cells.

23308591

NP_694542.1

NM_152997.3

Q8NFU4

9,700 Da

This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]

Function: Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells. Subcellular location: Secreted. Tissue specificity: Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. Ref.1. Post-translational modification: O-glycosylated with core 1 or possibly core 8 glycans. Ref.4

5 + Control Slides

115 USD

0.1 mL (Concentrate)

210

3 ml (Prediluted)

230

7 ml (Prediluted)

305

0.5 mL (Concentrate)

530