antibody

Desmin

MBS370062

3 ml

190 USD

monoclonal

mouse

nonconjugated

D33

Antibody

Desmin

Desmin

desmin; Desmin; desmin; OTTHUMP00000064865; intermediate filament protein; desmin

DES; DES; CSM1; CSM2; CMD1I; FLJ12025; FLJ39719; FLJ41013; FLJ41793

DESM_HUMAN

Monoclonal

IgG1/K

D33

Mouse

Store at 2 to 8 degree C in the dark.

55749932

NP_001918.3

NM_001927.3

P17661

53405 Da

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117293!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129!!Aurora B Signaling Pathway 138080!!Dilated Cardiomyopathy Pathway 121494!!Dilated Cardiomyopathy Pathway 121285!!Hypertrophic Cardiomyopathy (HCM) Pathway 114229!!Hypertrophic Cardiomyopathy (HCM) Pathway 106591!!Muscle Contraction Pathway 106261!!Striated Muscle Contraction Pathway 106262!!Striated Muscle Contraction Pathway 198903

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq]

Function: Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Subunit structure: Homopolymer. Interacts with DST. By similarity. Interacts with MTM1. Ref.10. Subcellular location: Cytoplasm. Involvement in disease: Defects in DES are the cause of myopathy myofibrillar desmin-related (MFM-DES) [. MIM:601419]; also known as desmin-related myopathy (DRM). A neuromuscular disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by myofibrillar destruction with intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. Ref.4 Ref.6 Ref.7 Ref.9 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.22Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [. MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Ref.5Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [. MIM:181400]. Kaeser syndrome is an autosomal dominant disorder with a peculiar scapuloperoneal distribution of weakness and atrophy. A large clinical variability is observed ranging from scapuloperoneal, limb grindle and distal phenotypes with variable cardiac or respiratory involvement. Facial weakness, dysphagia and gynaecomastia are frequent additional symptoms. Affected men seemingly bear a higher risk of sudden, cardiac death as compared to affected women. Histological and immunohistochemical examination of muscle biopsy specimens reveal a wide spectrum of findings ranging from near normal or unspecific pathology to typical, myofibrillar changes with accumulation of desmin. Sequence similarities: Belongs to the intermediate filament family.

3 ml

190 USD