antibody

Cytokeratin 35BH11

MBS370053

3 ml

225 USD

monoclonal

mouse

nonconjugated

35betaH11

Antibody

Cytokeratin 35BH11

Cytokeratin 35BH11

cytokeratin 8; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8; CK-8; keratin-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; keratin 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8

KRT8; KRT8; K8; KO; CK8; CYK8; K2C8; CARD2; CYK8

K2C8_HUMAN

Monoclonal

IgM

35betaH11

Mouse

Cytokeratin 8/35betaH11 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Store at 2 to 8 degree C in the dark.

Control: Prostate, Colon. Localization: Cytoplasmic

Reactivity Note: Paraffin, Frozen

Cytokeratin 8 belongs to the Type II (basic) subfamily of high molecular-weight keratins and exists in combination with cytokeratin 18. Cytokeratin 8 is primarily found in the non-squamous epithelia and is present in the majority of Adenocarcinomas and Ductal Carcinomas. It is absent in Squamous Cell Carcinomas. Hepatocellular Carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18. Anti-Cytokeratin 8/35betaH11 stains most Non-Squamous Epithelial tumors; Squamous tumors are negative for this antibody as a rule. This antibody stains Adenocarcinomas of the breast, ovary, gastrointestinal tract, thyroid, pancreas, bile duct, and salivary glands. This antibody does not react with skeletal muscle or nerve cells.

181573

P05787

53,704 Da

EGFR1 Signaling Pathway 198782!!Signaling Mediated By P38-alpha And P38-beta Pathway 138012

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq]

Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Ref.19. Subunit structure: Heterotetramer of two type I and two type II keratins. Keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. Ref.13 Ref.14 Ref.17 Ref.19 Ref.20 Ref.22 Ref.30. Subcellular location: Cytoplasm. Nucleus nucleoplasm. By similarity. Nucleus matrix. By similarity Ref.13 Ref.30. Tissue specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. Ref.13 Ref.19. Post-translational modification: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues. Ref.12. Involvement in disease: Defects in KRT8 are a cause of cirrhosis (CIRRH) [. MIM:215600]. Ref.34. Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). Sequence similarities: Belongs to the intermediate filament family.

3 ml

225 USD