bcl-6 RMab | MyBioSource MBS370008 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

bcl-6 RMab

catalog :

MBS370008

quantity :

5 + Control Slides

price :

115 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

RBT-bcl6

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS370008

products type :

Antibody

products full name :

bcl-6 RMab

products short name :

bcl-6

products name syn :

bcl-6 RMab

other names :

B-cell lymphoma 6 protein isoform 2; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein; BCL-5; BCL-6; protein LAZ-3; OTTHUMP00000209895; OTTHUMP00000209897; OTTHUMP00000209900; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; B-cell CLL/lymphoma 6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

products gene name :

bcl-6

other gene names :

BCL6; BCL6; BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; BCL5; LAZ3; ZBTB27; ZNF51

uniprot entry name :

BCL6_HUMAN

clonality :

Monoclonal

isotype :

IgG

clone :

RBT-bcl6

host :

Rabbit

reactivity :

Human

form :

Bcl-6 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

storage stability :

Store at 2 to 8 degree C in the dark.

other info1 :

Control: Tonsil, Lymph Node. Localization: Nuclear

other info2 :

Reactivity Note: Paraffin, Frozen

products description :

bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, Burkitt's Lymphoma, and the majority of the Reed-Sternberg cells in Nodular Lymphocyte-Predominant Hodgkin's Disease.Bcl-6 is also useful in identifying neoplastic cells in cases of nodular Lymphocyte-Predominant Hodgkin's Disease. In contrast, anti-bcl-6 rarely stains Mantle-Cell Lymphoma and MALT Lymphoma. bcl-6 expression is seen in approximately 45% of CD30+ Anaplastic Large-Cell Lymphomas but is consistently absent in other peripheral T-cell Lymphomas.

ncbi gi num :

197927147

ncbi acc num :

NP_001128210.1

ncbi gb acc num :

NM_001134738.1

uniprot acc num :

P41182

ncbi mol weight :

78,846 Da

ncbi pathways :

B Cell Receptor Signaling Pathway (198909); Direct P53 Effectors Pathway (137939); FoxO Family Signaling Pathway (138036); IL4-mediated Signaling Events Pathway (137933); Signaling Events Mediated By HDAC Class II Pathway (138062)

ncbi summary :

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq]

uniprot summary :

Function: Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis. Ref.7 Ref.12. Subunit structure: Homodimer. Interacts (via BTB domain) with BCOR; the interaction is direct. Interacts (via BTB domain) with NCOR2; the interaction is direct. Interacts with ZBTB7 and BCL6B. By similarity. Interacts with the catalytic domain of HDAC9. Ref.8 Ref.12. Subcellular location: Nucleus. Tissue specificity: Expressed in germinal center T and B cells and in primary immature dendritic cells. Ref.7 Ref.9. Induction: Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial lipopolysaccharides (LPS), CD40LG and zymosan. Ref.9. Domain: The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2. Post-translational modification: Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway. Involvement in disease: Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. Sequence similarities: Contains 1 BTB (POZ) domain.Contains 6 C2H2-type zinc fingers.

size1 :

5 + Control Slides

price1 :

115 USD

size2 :

3 ml (Prediluted)

price2 :

215

size3 :

0.1 mL (Concentrate)

price3 :

255

size4 :

7 ml (Prediluted)

price4 :

300

size5 :

1 mL (Concentrate)

price5 :

455

more info or order :

MyBioSource product webpage