antibody

Anti-BNP Antibody (Detection Ab)

MBS355823

1 mg

420 USD

monoclonal

mouse

nonconjugated

[2D6]

ELISA, enzyme immunoassay

Antibody

Anti-BNP Antibody (Detection Ab)

[BNP]

[Brain natriuretic peptide, BNP mAb (Mouse anti-human, clone # 2D6)-Capture Ab]

[natriuretic peptides B preproprotein; Natriuretic peptides B; natriuretic peptides B; natriuretic peptide B; Gamma-brain natriuretic peptide]

[BNP]

[NPPB; NPPB; BNP; BNP(1-32); BNP-32]

m

IgG2b

[2D6]

Mouse

Human

134

>95% by HPLC & SDS-PAGE

Liquid. Protein A or G purified and supplied in 0.01 M PBS (pH7.4) without preservative.

Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles.

ELISA (EIA), Chemiluminescence Immunoassays (CLIA), Flow Fluorenscence Immunmicrobeads Assay (FFIA)

Other applications have not been tested . The optimal dilutions should not be determined by end user. Matched antibody pair: . Capture Ab: BNP: mAb (clone #B4). Detection Ab: BNP mAb ( clone#2D6)

Background: Brain natriuretic peptide or B-type natriuretic peptide (BNP) (also ventricular natriuretic peptide or natriuretic peptide B) is a 32-amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes). BNP is secreted attached to a 76–amino acid N-terminal fragment in the prohormone called NT-proBNP (BNPT), which is biologically inactive. BNP is synthesized as a 134-amino acid preprohormone (preproBNP), encoded by the human gene NPPB.

1. Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G (1989). "Calcium Calmodulin antagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes". In Kaufmann W, Wambach G. Handbook Endocrinology of the Heart. Berlin: Verlag: Springer. pp. 233-4.

4505433

NP_002512.1

NM_002521.2

P16860

MicroRNAs In Cardiomyocyte Hypertrophy Pathway (198784); CGMP-PKG Signaling Pathway (983748); CGMP-PKG Signaling Pathway (985584)

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

1 mg

420 USD