protein

Procalcitonin, PCT

MBS355754

0.01 mg

200 USD

Recombinant Protein

Procalcitonin, PCT

[Procalcitonin]

[PCT]

E. Coli

>95% by SDS-PAGE

Lyophilized from 0.01 M PBS (pH7.4) with 2% BSA and 0.03% Proclin 300.

Shipping: Blue ice. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles

ELISA (EIA), SDS-PAGE. Other applications have not been tested. The optimal dilutions should be determined by end user.

Recombinant human PCT protein with 6×His tag at N-terminal. Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It iscomposed of 116 amino acids and is produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine. The level of procalcitonin in the blood stream of healthy individuals is below the limit of detection (10 pg/mL) of clinical assays. Itslevel rises in a response to a proinflammatory stimulus, especially of bacterial origin. Measurement of PCT concentrations during multiple organ dysfunction syndrome provides more information about the severity and the course of the disease than that of CRP. It can be used as a marker of severe sepsis caused by bacteria and generally grades well with the degree of sepsis, although levels of procalcitonin in the blood are very low. PCT has the greatest sensitivity (85%) and specificity (91%) for differentiating patients with systemic inflammatory response syndrome (SIRS) from those with sepsis, when compared with IL-2, IL-6, IL-8, CRP and TNF-alpha.

0.01 mg

200 USD