protein

Human Epididymis protein 4, HE4 (Pichia pastoris)

MBS355745

0.1 mg

390 USD

Recombinant Protein

Human Epididymis protein 4, HE4 (Pichia pastoris)

[Epididymis protein 4]

[Human epididymis protein 4,HE4, WAP four-disulfide core domain protein 2, WFDC2]

[HE4]

Pichia pastoris

>95% by SDS-PAGE

Liquid. Each vial contains Tris-HCL (pH7.4 ± 0.2) with 0.02% sodium azide.

Shipping: Blue Ice. Upon receipt, aliquot and store at -20°C or -80°C for long term.Avoid repeated freeze and thaw cycles.

ELISA, SDS-PAGE. Other applications have not been tested.

The optimal dilutions should be determined by end user.

Background: WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4) is a protein that in humans is encoded by the WFDC2 gene. This gene is amplified in ovarian carcinomas, whereas its expression in normal tissues, including ovary, is low. Although the function of the HE4 protein is unknown,it is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. HE4 is a secreted glycoprotein that is overexpressed by serous and endometrioid EOCs (epithelial ovarian carcinomas). Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types of EOCs.

0.1 mg

390 USD