protein

PGC pepsinogen II, PGII Protein (Active)

MBS355634

0.1 mg

475 USD

Recombinant Protein

PGC pepsinogen II, PGII Protein (Active)

PGC pepsinogen II, PGII

PGII

E Coli

>95% by SDS-PAGE

Liquid

1 mg/ml

Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term. Avoid repeated freeze and thaw cycles.

ELISA (EIA), SDS-PAGE. Other applications have not been tested. The optimal dilutions should be determined by end user

Storage Buffer: Each vial contains Tris-HCl (pH7.4 0.2) with 0.2% NaN3.

Recombinant full length human PG II protein with molecular weight 42 kDa. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. It consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41-amino acid segment from the amino end. There are 2 related pepsinogen systems in man: PGA, formerly PG I, precursor of pepsin A, and PGC, formerly PG II, precursor of pepsin C. In human gastric mucosa, 2 immunologically distinct classes of pepsinogen are synthesized. PG1 is restricted to the corpus, while PG2 is found throughout the stomach as well as in the proximal duodenum. PG1 is found in serum and urine in a ratio of about 1 to 10. PG2 is present in serum and seminal fluid but only trace amounts are found in urine. Serum PG1 and PG2 apparently originate from the stomach in the main, because the levels are very low after gastrectomy. PG2 in seminal fluid probably originates from the prostate.

0.1 mg

475 USD