protein

SCCA2 / SerpinB4 Protein (Active)

MBS355581

0.1 mg

780 USD

Recombinant Protein

SCCA2 / SerpinB4 Protein (Active)

SCCA2

SCCA2

E Coli

>95% by SDS-PAGE

Liquid

0.65 mg/ml

Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term. Avoid repeated freeze and thaw cycles.

ELISA (EIA), SDS-PAGE

Background: Squamous cell carcinoma antigen (SCCA) is a member of the ovalbumin family of serine proteinase inhibitors (serpins). SCCA is detected in the superficial and intermediate layers of normal squamous epithelium, whereas the mRNA is detected in the basal and subbasal levels. A neutral form of the protein (SCCA1, or SERPINB3) is found in normal and some malignant squamous cells, whereas an acidic form (SCCA2, or SERPINB4) is detected exclusively in tumor cells and in the circulation of patients with squamous cell tumors. SCCA1 shares 92% amino acid identity with SCCA2. Thus, the appearance of the acidic fraction of SCCA is correlated with more aggressive tumors. Ray et al. (2005) proposed that IL-4- and IL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and by suppressing the production, and most likely by interfering with the signaling of these cytokines, UG inhibits SCCA gene expression associated with airway inflammation in asthma.

0.1 mg

780 USD