catalog number :
MBS355200
products full name :
Anti-CD79alpha antibody
products short name :
[CD79 alpha]
products name syn :
[Polyclonal Anti- CD79alpha; Polyclonal Anti- CD79a]
products gene name :
[CD79 alpha]
reactivity :
Human, mouse
purity :
Immunogen affinity purified
storage stability :
Store at 4°C after thawing (1 week). Aliquot and store at -20° C for long term (at least one year). Avoid repeated freeze and thaw cycles
tested application :
Western Blot (WB), Immunocytochemistry (ICC)
app notes :
WB (1:1000-2000); ICC (1:50-100)
image1 heading :
Western Blot (WB)
image2 heading :
Testing Data
other info1 :
Immunogen: A synthetic peptide (conjugated to KLH) corresponding to the region of CD79 .
other info2 :
Storage Buffer: In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide
products description :
CD79a molecule, immunoglobulin-associated alpha, also known as mb-1, is expressed in B lymphocytes and is part of the B-cell antigen receptor complex.[1] This complex consists of a clonally restricted antigen-binding molecule (membrane Ig) associated noncovalently with an 'invariant' transducer/transporter complex. It is required in cooperation with CD79b for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. [2] It is interacts with and increases activity of some Src-family tyrosine kinases. And also represses BCR signaling during development of immature B-cells. [3]
products references :
1. Ha, H., Kubagawa, H., Burrows, P. D. Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene. J. Immun. 148: 1526-1531, 1992. 2. Luisiri P., Lee Y.J., Eisfelder B.J., Clark M.R. "Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex." J. Biol. Chem. 271:5158-5163(1996) 3. Tseng J., Eisfelder B.J., Clark M.R. "B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta." Blood 89:1513-1520(1997)