product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-CD133 antibody
catalog :
MBS355164
quantity :
0.1 mg
price :
285 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
product information
catalog number :
MBS355164
products type :
Antibody
products full name :
Anti-CD133 antibody
products short name :
CD133
products name syn :
Polyclonal Anti- CD133
products gene name :
CD133
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, mouse, rat
purity :
Immunogen affinity purified
form :
Liquid
storage stability :
Store at 4 degree C after thawing (1 week). Aliquot and store at -20 degree C for long term (at least one year). Avoid repeated freeze and thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)
app notes :
WB (1:1000). IHC-P (1:200). ICC (1:200). FC (1:100-200). Other applications have not been tested. The optimal dilutions should be determined by end user
products description :
Background/Introduction: CD133, originally known as AC133.1 CD133 is a glycoprotein also known in humans and rodents as Prominin 1 (PROM1).2 It is a member of pentaspan transmembrane glycoproteins (5-transmembrane, 5-TM), which specifically localize to cellular protrusions. Most of the PROM1 gene is contained in 23 exons distributed over more than 50 kb of genomic sequence.3 CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastoma, neuronal and glial stem cells, various pediatric brain tumors, as well as adult kidney, mammary glands, trachea, salivary glands, placenta, digestive tract, testes, and some other cell types. CD133-positive tumor cells represent the cellular population that confers glioma radioresistance and could be the source of tumor recurrence after radiation. Targeting DNA damage checkpoint response in cancer stem cells may overcome this radioresistance and provide a therapeutic model for malignant brain cancers4.
products references :
1. Yin A, et al (1997). "AC133, is a novel marker for human hematopoietic stem and progenitor cells". Blood 90 (12): 5002-5012. 2. Corbeil D, Fargeas C, Huttner W (2001). "Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein". Biochem Biophys Res Commun 285 (4): 939-44. 3. Maw, M. A., Corbeil, D., Koch, J., Hellwig, A., Wilson-Wheeler, J. C., Bridges, R. J., Kumaramanickavel, G., John, S., Nancarrow, D., Roper, K., Weigmann, A., Huttner, W. B., Denton, M. J. A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. Hum. Molec. Genet. 9: 27-34, 2000.4. Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., Dewhirst, M. W., Bigner, D. D., Rich, J. N. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444: 756-760, 2006.
size1 :
0.1 mg
price1 :
285 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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