antibody

PKC Gamma

MBS352235

1 Bottle

300 USD

polyclonal

rabbit

nonconjugated

Antibody

PKC Gamma

PKC Gamma

Protein Kinase C g (Human, Rat)

Protein kinase C gamma type; Protein kinase C gamma type; protein kinase C gamma type; OTTHUMP00000067291; protein kinase C, gamma

PRKCG; PRKCG; PKCC; PKCG; SCA14; MGC57564; PKC-gamma; PKCG

KPCG_HUMAN

Polyclonal

Rabbit

697

Radioimmunoassay

RIA Grade Antibodies

462455

P05129.3

P05129

P05129

78,448 Da

African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Aldosterone-regulated Sodium Reabsorption Pathway 130626!!Aldosterone-regulated Sodium Reabsorption Pathway 130590!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Ca-dependent Events Pathway 106497!!CaM Pathway 106468!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Calcium Signaling Pathway 83050

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq]

Function: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain. Subunit structure: Interacts with CDCP1. Ref.5. Tissue specificity: Expressed in Purkinje cells of the cerebellar cortex. Ref.13. Involvement in disease: Defects in PRKCG are the cause of spinocerebellar ataxia type 14 (SCA14) [. MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA14 is an autosomal dominant cerebellar ataxia (ADCA). Ref.13. Sequence similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.

1 Bottle

300 USD