Rabbit Anti-Human Insulin-like Growth Factor II Serum | MyBioSource MBS352120 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human Insulin-like Growth Factor II Serum

catalog :

MBS352120

quantity :

0.1 mL

price :

430 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS352120

products type :

Antibody

products full name :

Rabbit Anti-Human Insulin-like Growth Factor II Serum

products short name :

[IGF-2 (Human)]

other names :

[insulin-like growth factor II; Insulin-like growth factor II; insulin-like growth factor II; somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015; OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158; OTTHUMP00000220677; insulin-like growth factor type 2; insulin-like growth factor 2 (somatomedin A); Somatomedin-A]

other gene names :

[IGF2; IGF2; IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734]

uniprot entry name :

IGF2_HUMAN

clonality :

Polyclonal

host :

Rabbit

specificity :

The antisera are specific for the peptide hormone and are suitable for immunoprecipitation of human IGF-II.

form :

Dilute the lyophilized antisera with 0.1 ml of 10 mg/ml BSA in PBS for the equivalent of whole antisera, or with additional buffer for more dilute antisera.

storage stability :

Store aliquots frozen at -20 degree C. Once aliquots are thawed store at 4 degree C (avoid repeated freeze thaw cycles).

tested application :

Immunoprecipitation

app notes :

We recommend that the end user perform a titration experiment (starting at a dilution of 1:250) on their sample using their specific techniques since different laboratories use various techniques.

other info1 :

Host Note: The pooled antisera were raised in rahbits whi~h were immunized with human insulin-like growth factor II covalently attached onto a carrier protein (bovine thyroglobulin).

other info2 :

Pooled Antisera Specificity: Polypeptide: Insulin-like growth factor II (human); % Cross Reactivity: 100. Polypeptide: IGF-1 (human); % Cross Reactivity: 1. Polypeptide: Insulin (human); % Cross Reactivity: <1. Polypeptide: Atrial natriuretic polypeptide (human); % Cross Reactivity: 0. Polypeptide: EGF; % Cross Reactivity: 0. Polypeptide: TGFalpha; % Cross Reactivity: 0

products categories :

Immunoprecipitating Antibodies

ncbi gi num :

189955

uniprot acc num :

P01344

ncbi pathways :

Apoptosis Pathway (198797); Diabetes Pathways (105902); Endochondral Ossification Pathway (198812); Hedgehog Signaling Pathway (198835); Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

ncbi summary :

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

uniprot summary :

Function: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Ref.27Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. Ref.27. Subcellular location: Secreted. Post-translational modification: O-glycosylated with a core 1 or possibly core 8 glycan. Ref.26 Ref.29. Polymorphism: Genetic variations in IGF2 are associated with body mass index (BMI). The BMI is a statistical measurement which compares a person's weight and height. Involvement in disease: Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [. MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. Sequence similarities: Belongs to the insulin family. Mass spectrometry: Molecular mass is 7469.4 Da from positions 25 - 91. Determined by MALDI. Ref.24 Ref.25Molecular mass is 7398.3 Da from positions 26 - 91. Determined by MALDI. Ref.24 Ref.25

size1 :

0.1 mL

price1 :

430 USD

more info or order :

MyBioSource product webpage