product summary
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company name :
MyBioSource
product type :
protein
product name :
Hepatocyte Growth Factor-A (HGF-A)
catalog :
MBS343198
quantity :
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price :
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more info or order :
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image
image 1 :
MyBioSource MBS343198 image 1
product information
catalog number :
MBS343198
products type :
Recombinant Protein
products full name :
Hepatocyte Growth Factor-A (HGF-A)
products short name :
[Hepatocyte Growth Factor-A (HGF-A)]
products name syn :
[Scatter Factor; Lung Fibroblast-Derived Mitogen, Hepatopoietin A; Hepatocyte Growth Factor-A]
other names :
[hepatocyte growth factor activator isoform 2 preproprotein; Hepatocyte growth factor activator; hepatocyte growth factor activator; HGF activator]
products gene name :
[HGF-A]
other gene names :
[HGFAC; HGFAC; HGFA; HGF activator; HGFA]
uniprot entry name :
HGFA_HUMAN
sequence length :
655
purity :
>95%
form :
Liquid
concentration :
0.75 mg/ml
storage stability :
Store at -20°C
image1 heading :
SDS-PAGE
other info1 :
Total Volume: 1.34 ml. Total Protein: 1000 ug
other info2 :
Buffer: 25mM Na. Acetate pH 4.8, 1mM EDTA 50% Glycerol.
products categories :
Recombinant Proteins; Hepatocyte Growth Factor A (HGF-A)
products description :
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase-signalling cascade. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. Recombinant HGF-A comprises a 463 amino acid fragment (32-494) corresponding to the mature HGF-A protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.
products references :
Miyazawa, K. et al (1993) Journal of Biological Chemistry 268: 10024-10028. Shimomura T. et al (1992) Cytotechnology 8: 219-229.
ncbi gi num :
4504383
ncbi acc num :
NP_001519.1
ncbi gb acc num :
NM_001528.3
uniprot acc num :
Q04756
ncbi mol weight :
57.8kDa
ncbi summary :
This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
uniprot summary :
HGFAC: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. Belongs to the peptidase S1 family. Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.-; Protease. Chromosomal Location of Human Ortholog: 4p16. Molecular Function: serine-type peptidase activity
size1 :
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price1 :
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more info or order :
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company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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