protein

HGF-A (Western Blot Control)

MBS343197

0.01 mg

235 USD

Recombinant Protein

HGF-A (Western Blot Control)

HGF-A (Western Blot Control)

HGF-A; HGF-A chain; Hepatocyte Growth Factor-A (Western Blot Control); Scatter Factor; Lung Fibroblast-Derived Mitogen, Hepatopoietin A

hepatocyte growth factor activator preproprotein; Hepatocyte growth factor activator; hepatocyte growth factor activator; OTTHUMP00000115316; OTTHUMP00000217082; HGF activator

HGF-A

HGFAC; HGFAC; HGFA; MGC138395; MGC138397

HGFA_HUMAN

Single band on Western blot.

Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).

Human Recombinant Protein

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase-signalling cascade. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. Our recombinant HGF-A comprises a 463 amino acid fragment (32-494) corresponding to the mature HGF-A protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Miyazawa, K. et al (1993) Journal of Biological Chemistry 268 10024-10028. Shimomura T. et al (1992) Cytotechnology 8 : 219-229.

4504383

NP_001519.1

NM_001528.2

Q04756

70,682 Da

The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. [provided by RefSeq]

Function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. Subunit structure: Heterodimer of a short chain and a long chain linked by a disulfide bond. Subcellular location: Secreted. Note: Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. Tissue specificity: Liver. Sequence similarities: Belongs to the peptidase S1 family.Contains 2 EGF-like domains.Contains 1 fibronectin type-I domain.Contains 1 fibronectin type-II domain.Contains 1 kringle domain.Contains 1 peptidase S1 domain. Caution: It is uncertain whether Met-1 is the initiator.

0.01 mg

235 USD