protein

Fractalkine (25-100) (Western Blot Control)

MBS343189

0.01 mg

235 USD

Recombinant Protein

Fractalkine (25-100) (Western Blot Control)

Fractalkine (25-100) (Western Blot Control)

Fractalkine (25-100); Fractalkine (Western Blot Control); Chemokine, CX3C Motif, Ligand 1; CX3CL1; Small Inducible Cytokine Subfamily D, Member 1; SCYD1; Neurotactin; NTT; NTN

fractalkine; Fractalkine; fractalkine; OTTHUMP00000164674; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); chemokine (C-X3-C motif) ligand 1; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1

CX3CL1; CX3CL1; NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin; FKN; NTT; SCYD1

X3CL1_HUMAN

397

Single band on Western blot.

Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).

Human Recombinant Protein

Fractalkine is a large cytokine protein containing multiple domains and is the only known member of the CX3C chemokine family. Fractalkine is produced as a long protein (with 373-amino acid in humans) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the surface of certain cells. Fractalkine elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1. Our recombinant Fractalkine comprises a 76 amino acid fragment (25-100) corresponding to the chemokine domain of the fractalkine protein and is expressed in E. coli with an aminoterminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Pan, Y. et al. (1997) Nature 387 : 611-617. Bazan, J.F. et al. (1997) Nature 385 : 640-644.

4506857

NP_002987.1

NM_002996.3

P78423

42,203 Da

Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Direct P53 Effectors Pathway 137939!!GPCR Ligand Binding Pathway 161020!!Peptide Ligand-binding Receptors Pathway 106358!!Signaling By GPCR Pathway 106356

Function: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Subunit structure: Monomer. Subcellular location: Cell membrane; Single-pass type I membrane protein. Processed fractalkine: Secreted. Tissue specificity: Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Induction: By TNF and IL1/interleukin-1 in pulmonary endothelial cells and umbilical vein endothelial cells. Post-translational modification: A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form. By similarity.O-glycosylated with core 1 or possibly core 8 glycans. Ref.4. Sequence similarities: Belongs to the intercrine delta family.

0.01 mg

235 USD