protein

Pro-Matrix Metalloproteinase 9 (PRO MMP-9)

MBS343172

0.01 mg

220 USD

Recombinant Protein

Pro-Matrix Metalloproteinase 9 (PRO MMP-9)

Pro-Matrix Metalloproteinase 9 (PRO MMP-9)

Pro-MMP 9, Matrix metalloproteinase 9, gelatinase B, 92kD gelatinase, 92kD type IV collagenase precursor, CLG4B, GELB

pro-MMP-9, partial; Pro-MMP-9; matrix metalloproteinase-9; matrix metallopeptidase 9; Pro-MMP-9

PRO MMP-9

Mmp9; Mmp9; Clg4b; Gel B; MMP-9; B/MMP9; AW743869; pro-MMP-9

Q91ZS5_MOUSE

56

>95% by SDS-PAGE

Liquid

Buffer: Buffered 50% glycerol

Recombinant Proteins; MMP-9 (Pro Form)

MMP-9 is secreted as a 92kDa zymogen. Cleavage of pro-MMP-9 results in the active enzyme with a molecular weight of ~82kDa. MMP-9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodelling, wound healing, Tumor growth and metastasis. Recombinant human Pro-MMP-9 comprises a 688aa fragment (20-707) corresponding to the pro form of the protein minus the signal peptide and is expressed in E Coli with an N-terminal 6xHis tag. This product is not intended for therapeutic use

Pourmotabbed, T et al., Biochim Biophys Acta. 1204 (1):97-107(1994). Romanic, AM. et al., Stroke 29 (5): 1020-1030 (1998).

15420890

AAK97498.1

Q91ZS5

6,347 Da

Activation Of Matrix Metalloproteinases Pathway (1367347); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1367336); Axon Guidance Pathway (1366709); Bladder Cancer Pathway (83308); Bladder Cancer Pathway (527); Collagen Degradation Pathway (1367348); Collagen Formation Pathway (1367334); Degradation Of The Extracellular Matrix Pathway (1367346); Developmental Biology Pathway (1366708); EPH-Ephrin Signaling Pathway (1366740)

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]

0.01 mg

220 USD

0.1 mg

565

1 mg

2580