MyBioSource

protein

14-3-3-Gamma

MBS343170

0.01 mg

190 USD

MBS343170

Recombinant Protein

14-3-3-Gamma

14-3-3 Gamma

14-3-3-y; 14-3-3 gamma; Tyrosine 3-monooxygenase / Tryptophan 5-monooxygenase activation protein gamma isoform; Protein kinase C inhibitor protein; KCIP-1

14-3-3 protein gamma; 14-3-3 protein gamma; 14-3-3 protein gamma; KCIP-1; 14-3-3 gamma; OTTHUMP00000161136; protein kinase C inhibitor protein 1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Protein kinase C inhibitor protein 1

14-3-3-y

YWHAG; YWHAG; 14-3-3GAMMA; N/A

1433G_HUMAN

247

>95% by SDS-PAGE

Liquid

Human Recombinant Protein

14-3-3 is a general name given to a family of acidic, soluble, ubiquitously expressed 28kDa proteins that are the products of related but separate genes. They are considered isoforms and are named eta (eta) , gamma (gamma) , delta/zeta (delta / Xi) , alpha/beta (alpha / beta) , theta/tau (theta / tau) , sigma (sigma) or epsilon (epsilon) . Interactions are generally mediated by phosphorylation of specific binding sites in the target proteins. 14-3-3 proteins can exist as monomers, homodimers and heterodimers. Our recombinant 14-3-3 gamma comprises a 246 amino acid fragment (2-247) corresponding to the 14-3-3 gamma coding sequence and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Mhawech P. (2005) Cell Research 15 (4); 228-236.

21464101

NP_036611.2

NM_012479.3

P61981

28,303 Da

Calcium Regulation In The Cardiac Cell Pathway 198906!!Cell Cycle, Mitotic Pathway 105765!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Centrosome Maturation Pathway 105807!!Class I PI3K Signaling Events Mediated By Akt Pathway 138020!!ErbB1 Downstream Signaling Pathway 138057!!FoxO Family Signaling Pathway 138036!!G2/M Transition Pathway 105801

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq]

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Subunit structure: Homodimer. Interacts with SAMSN1. By similarity. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Ref.1 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16. Subcellular location: Cytoplasm. Tissue specificity: Highly expressed in brain, skeletal muscle, and heart. Ref.2. Post-translational modification: Phosphorylated by various PKC isozymes. Ref.1 Ref.6. Sequence similarities: Belongs to the 14-3-3 family.

0.01 mg

190 USD