protein

14-3-3-Gamma (Western Blot Control)

MBS343169

0.01 mg

180 USD

Recombinant Protein

14-3-3-Gamma (Western Blot Control)

14-3-3-Gamma

14-3-3-y

14-3-3 protein gamma; 14-3-3 protein gamma; 14-3-3 protein gamma; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Protein kinase C inhibitor protein 1; KCIP-1

14-3-3-Gamma

YWHAG; YWHAG; PPP1R170; 14-3-3GAMMA; KCIP-1

1433G_HUMAN

247

>= 95% (SDS PAGE)

Liquid

Buffer: Buffered 50% glycerol

Recombinant Proteins; 14-3-3-Gamma

14-3-3 is a general name given to a family of acidic, soluble, ubiquitously expressed 28kDa proteins that are the products of related but separate genes. They are considered isoforms and are named eta, gamma, delta/zeta, alpha/beta, theta/tau, sigma or epsilon. Interactions are generally mediated by phosphorylation of specific binding sites in the target proteins. 14-3-3 proteins can exist as monomers, homodimers and heterodimers. Recombinant 14-3-3 gamma comprises a 246 amino acid fragment (2-247) corresponding to the 14-3-3 gamma coding sequence and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.

Mhawech P. (2005) Cell Research 15 (4); 228-236.

21464101

NP_036611.2

NM_012479.3

P61981

28,303 Da

AURKA Activation By TPX2 Pathway (1383018); Activation Of BAD And Translocation To Mitochondria Pathway (1270271); Activation Of BH3-only Proteins Pathway (1270270); Anchoring Of The Basal Body To The Plasma Membrane Pathway (1268847); Apoptosis Pathway (1270262); Assembly Of The Primary Cilium Pathway (1268846); Calcium Regulation In The Cardiac Cell Pathway (198906); Cell Cycle Pathway (1269741); Cell Cycle Checkpoints Pathway (1269742); Cell Cycle, Mitotic Pathway (1269763)

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

14-3-3 gamma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Interacts with SAMSN1. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. Highly expressed in brain, skeletal muscle, and heart. Belongs to the 14-3-3 family. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 7q11.23. Cellular Component: cytoplasmic vesicle membrane; cytosol; focal adhesion; membrane. Molecular Function: insulin-like growth factor receptor binding; protein binding; protein kinase C binding. Biological Process: G2/M transition of mitotic cell cycle; regulation of neuron differentiation; regulation of synaptic plasticity

0.01 mg

180 USD