protein

Platelet Derived Growth Factor A Chain (Western Blot Control)

MBS343163

0.01 mg

200 USD

Recombinant Protein

Platelet Derived Growth Factor A Chain (Western Blot Control)

Platelet Derived Growth Factor A Chain (Western Blot Control)

PDGF-A; PDGF-A Chain; Platelet Derived Growth Factor A (Western Blot Control); Platelet derived growth factor A; PDGF1; platelet derived growth factor alpha

platelet-derived growth factor subunit A isoform 2 preproprotein; Platelet-derived growth factor subunit A; platelet-derived growth factor subunit A; PDGF-1; PDGF A-chain; PDGF subunit A; OTTHUMP00000199955; OTTHUMP00000199956; platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; platelet-derived growth factor alpha polypeptide; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide

PDGF-A

PDGFA; PDGFA; PDGF1; PDGF-A; PDGF1

PDGFA_HUMAN

211

Single band on Western blot.

Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).

Human Recombinant Protein

The term 'PDGF' refers to a family of disulphide bondlinked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets. They act as potent mitogens for almost all mesenchymally-derived cells. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family - PDGF A, PDGF B, PDGF C and PDGF D. Two distinct types of PDGF-A exist - a short form that is soluble and a long form that is retained by the extracellular matrix. Our recombinant PDGF-A comprises a 110 amino acid fragment (87-196) corresponding to the mature PDGF-A short chain protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Raines, E.W. & Ross, R. (1982) J. Biol. Chem. 257(9) : 5154-5160. Bonthron, D.T. et al. (1988). Proc. Natl. Acad. Sci USA 85(5): 1492-1496.

15208656

NP_148983.1

NM_033023.4

P04085

24,043 Da

Ceramide Signaling Pathway 138023!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response Pathway 198794!!Down-stream Signal Transduction Pathway 106385!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!Formation Of Platelet Plug Pathway 106029!!Gap Junction Pathway 83072

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq]

Function: Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Subunit structure: Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4. Ref.11 Ref.12 Ref.13. Subcellular location: Secreted. Domain: The long form contains a basic insert which acts as a cell retention signal. Miscellaneous: A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. Sequence similarities: Belongs to the PDGF/VEGF growth factor family.

0.01 mg

200 USD