protein

Interleukin-10 (Western Blot Control)

MBS343159

0.01 mg

200 USD

Recombinant Protein

Interleukin-10 (Western Blot Control)

Interleukin-10 (Western Blot Control)

IL-10; Interleukin-10; IL-10; IL10; Cytokine synthesis inhibitory factor; CSIF

interleukin-10; Interleukin-10; interleukin-10; OTTHUMP00000034567; T-cell growth inhibitory factor; cytokine synthesis inhibitory factor; interleukin 10; Cytokine synthesis inhibitory factor

IL10

IL10; IL10; CSIF; TGIF; IL-10; IL10A; MGC126450; MGC126451

IL10_HUMAN

178

Single band on Western blot.

Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).

Human Recombinant Protein

Interleukin-10 is a multifunctional cytokine produced by a variety of cell types including T helper cells activated B cells and activated macrophages. Interleukin-10 regulates immune-mediated inflammation and modulates the function of cells such as lymphocytes, monocytes, natural killer cells and dendritic cells. Our recombinant Interleukin-10 comprises a 160 amino acid fragment (19-178) corresponding to the mature Interleukin-10 protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Fickenscher, H. et al. (2002) Trends Immunol. 23(2) : 89- 96.

10835141

NP_000563.1

NM_000572.2

P22301

20,517 Da

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The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Subunit structure: Homodimer. Subcellular location: Secreted. Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. Sequence similarities: Belongs to the IL-10 family.

0.01 mg

200 USD