protein

Vascular Endothelial Growth Factor Receptor-1 (Western Blot Control)

MBS343153

0.01 mg

200 USD

Recombinant Protein

Vascular Endothelial Growth Factor Receptor-1 (Western Blot Control)

Vascular Endothelial Growth Factor Receptor-1 (Western Blot Control)

VEGFR1; VEGFR-1; Vascular endothelial growth factor receptor-1 [precursor]; VEGFR-1; EC 2.7.1.112; Vascular permeability factor receptor; Tyrosine-protein kinase receptor FLT; FLT-1; Tyrosine-protein kinase FRT; FMS-like tyrosine kinase 1

vascular endothelial growth factor receptor 1 isoform 2; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor 1; FLT-1; VEGFR-1; OTTHUMP00000018183; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular permeability factor receptor

VEGFR1

FLT1; FLT1; FLT; VEGFR1; FLT; FRT

VGFR1_HUMAN

1338

Single band on Western blot.

Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).

Human Recombinant Protein

VEGFR-1 belongs to a family of five receptor tyrosine kinase receptors that are specific to a number of angiogenic factors including VEGF and PDGF, and are therefore thought to play a role in the angiogenic process. VEGFR-1 is expressed in two forms, predominantly on endothelial cells, giving rise to a full-length membrane bound receptor and a truncated soluble receptor. Elevated levels of the soluble form of this VEGF receptor may be used in the diagnosis of pathological conditions. Our recombinant VEGFR-1 comprises a 298 amino acid fragment (31-328) corresponding to the IgGlike domains 1-3 from the mature soluble VEGFR protein. VEGFR-1 is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Starovasnik, M. A et al. (1999) J. Mol. Biol. 296 (3) : 531- 544. Kanno, S. et al. (2000) Oncogene 19 (17) : 2138-2146.

229892220

NP_001153392.1

NM_001159920.1

P17948

150,769 Da

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478!!Glypican 1 Network Pathway 138010!!HIF-2-alpha Transcription Factor Network Pathway 137956!!Id Signaling Pathway 198871

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

Function: Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis. Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Subunit structure: Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1. Interacts with GNB2L1/RACK1. Ref.10. Subcellular location: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. Isoform sFlt1: Secreted. Tissue specificity: Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta. Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 7 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.

0.01 mg

200 USD