protein

Vascular Cell Adhesion Molecule-1

MBS343146

0.01 mg

200 USD

Recombinant Protein

Vascular Cell Adhesion Molecule-1

Vascular Cell Adhesion Molecule-1

VCAM-1; VCAM-1; Vascular cell adhesion molecule 1, INCAM-100, Vascular cell adhesion protein 1 precursor, CD-106 antigen

vascular cell adhesion molecule-1; Vascular cell adhesion protein 1; vascular cell adhesion protein 1; CD106 antigen; OTTHUMP00000012650; OTTHUMP00000012651; OTTHUMP00000012652; OTTHUMP00000038305; vascular cell adhesion molecule 1; INCAM-100

VCAM-1

VCAM1; VCAM1; CD106; MGC99561; INCAM-100; DKFZp779G2333; L1CAM

VCAM1_HUMAN

739

>95% by SDS-PAGE

Liquid

Human Recombinant Protein

VCAM-1 is a cell surface sialoglycoprotein expressed by cytokine activated endothelium. The protein has a number of functions including the regulation of leukocyte migration, leukocyte-endothelial cell adhesion and signal transduction and may play a role in a number of inflammatory diseases. Our recombinant VCAM comprises a 674 amino acid fragment (25-698) corresponding to the mature extracellular VCAM protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Steeber, D. A & Tedder, T.F. (2000) Immuno. Res. 22(2- 3) : 299- 317. Albelda, S.M et al. (1994) FASEB J. 8(8): 504-512.

340194

AAA61269.1

P19320

81,276 Da

Adaptive Immunity Signaling Pathway 366160!!African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cellular Roles Of Anthrax Toxin Pathway 138076!!Cytokine Signaling In Immune System Pathway 366171!!HTLV-I Infection Pathway 373901!!HTLV-I Infection Pathway 373889!!Immune System Pathway 106386

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq]

Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. Subunit structure: Binds to ECMV-D capsid proteins and acts as a receptor for this virus. Subcellular location: Membrane; Single-pass type I membrane protein. Tissue specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. Induction: By cytokines (e.g. IL-1, TNF-alpha). Domain: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion. Ref.12. Post-translational modification: Sialoglycoprotein. Sequence similarities: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

0.01 mg

200 USD