catalog number :
MBS343131
products type :
Recombinant Protein
products full name :
S100A11 (Western Blot Control)
products short name :
S100A11 (Western Blot Control)
products name syn :
S100A11; S100A11; Calgizzarin, S100C
other names :
S100 calcium binding protein A11 (calgizzarin); Protein S100-A11; protein S100-A11; MLN 70; calgizzarin; protein S100-C; OTTHUMP00000015271; metastatic lymph node gene 70 protein; S100 calcium-binding protein A11 (calgizzarin); S100 calcium binding protein A11; Calgizzarin; Metastatic lymph node gene 70 protein; MLN 70; Protein S100-C; S100 calcium-binding protein A11
products gene name :
S100A11
other gene names :
S100A11; S100A11; MLN70; S100C; MLN70; S100C
uniprot entry name :
S10AB_HUMAN
purity :
2 bands on Western blot at 17 and 34 kDa, respectively representing monomeric and dimeric form
form :
Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1%(w/v) SDS, 0.1%(w/v) Bromophenol Blue, 2.5% Glycerol).
products categories :
Human Recombinant Protein
products description :
The S100 family of proteins contain two EF-hand calcium-binding motifs and are thought to be involved in the regulation of a number of cellular processes including cell cycle progression and differentiation. This protein may function in motility, invasion and tubulin polymerisation. Our recombinant human S100A11 is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
products references :
Donato R. (2003) Microsc Res Tech. 60(6): 540-41.
ncbi summary :
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq]
uniprot summary :
Function: Facilitates the differentiation and the cornification of keratinocytes. Ref.16. Subunit structure: Homodimer; disulfide-linked. Ref.16. Subcellular location: Cytoplasm. Nucleus Ref.16. Post-translational modification: Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation. Miscellaneous: Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. Sequence similarities: Belongs to the S-100 family.Contains 2 EF-hand domains.