protein

S100 Beta Chain

MBS343126

0.01 mg

190 USD

Recombinant Protein

S100 Beta Chain

S100 Beta Chain

S100B; S100 beta chain; NEF, S100, S100B, S-100 protein beta chain, S-100 calcium binding protein beta chain, S100 calcium binding protein beta (neural)

S100B; Protein S100-B; protein S100-B; OTTHUMP00000115888; S-100 protein subunit beta; S-100 calcium-binding protein, beta chain; S100 calcium-binding protein, beta (neural); S100 calcium binding protein B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B

S100B

S100B; S100B; NEF; S100; S100-B; S100beta

S100B_HUMAN

>95% by SDS-PAGE

Liquid

Human Recombinant Protein

S100 proteins belong to a family of EF-hand calcium binding proteins that exist mostly as dimers of the 20 currently identified individual S100 monomers. The S100B homodimer is expressed in cells of the central nervous system, glial cells and in certain peripheral cells e.g. Schwann cells, melanocytes, adipocytes and chondrocytes. The determination of S100B in serum levels may be used to monitor the extent of brain injury and malignant melanoma. Our recombinant S100 beta -chain comprises a 91 amino acid fragment (2-92) corresponding to processed S100 beta -chain and is expressed in E. coli with an aminoterminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

Heizmann, C.W. (1998) Biometals 11 (4): 383-397. Rothermundt, M. et al. (2003) Microsc. Res. Tech. 60 (6): 614-632.

49457242

P04271

10,713 Da

Activated TLR4 Signalling Pathway 106400!!Advanced Glycosylation Endproduct Receptor Signaling Pathway 187092!!Immune System Pathway 106386!!Innate Immunity Signaling Pathway 106387!!MyD88 Cascade Initiated On Plasma Membrane Pathway 205107!!MyD88 Dependent Cascade Initiated On Endosome Pathway 187081!!MyD88-independent Cascade Initiated On Plasma Membrane Pathway 106401!!MyD88:Mal Cascade Initiated On Plasma Membrane Pathway 106390!!NFkB And MAP Kinases Activation Mediated By TLR4 Signaling Repertoire Pathway 187089!!RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways 187097

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq]

Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Subunit structure: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. By similarity. The S100B dimer interacts with two molecules of CAPZA1. Ref.8. Subcellular location: Cytoplasm. Nucleus Ref.8. Tissue specificity: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Miscellaneous: In addition to metal-ion binding, this protein is involved with the regulation of protein phosphorylation in brain tissue. Sequence similarities: Belongs to the S-101 family.Contains 2 EF-hand domains.

0.01 mg

190 USD