Rantes (Western Blot Control) | MyBioSource MBS343121 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

protein

product name :

Rantes (Western Blot Control)

catalog :

MBS343121

quantity :

0.01 mg

price :

200 USD

product information

catalog number :

MBS343121

products type :

Recombinant Protein

products full name :

Rantes (Western Blot Control)

products short name :

Rantes (Western Blot Control)

products name syn :

RANTES; CCL5; Chemokine (C-C motif) ligand 5; T-cell specific RANTES protein; T-cell specific protein P288; beta chemokine RANTES precursor; small inducible cytokine A5; SIS delta; TCP288

other names :

RANTES; C-C motif chemokine 5; C-C motif chemokine 5; eoCP; SIS-delta; OTTHUMP00000163880; OTTHUMP00000197106; beta-chemokine RANTES; small-inducible cytokine A5; T-cell specific protein p288; t cell-specific protein P228; T-cell-specific protein RANTES; eosinophil chemotactic cytokine; small inducible cytokine A5 (RANTES); small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted; chemokine (C-C motif) ligand 5; EoCP; Eosinophil chemotactic cytokine; SIS-delta; Small-inducible cytokine A5; T cell-specific protein P228; TCP228; T-cell-specific protein RANTES

other gene names :

CCL5; CCL5; SISd; SCYA5; RANTES; TCP228; D17S136E; MGC17164; D17S136E; SCYA5

uniprot entry name :

CCL5_HUMAN

sequence length :

purity :

Single band on Western blot

form :

Liquid. Supplied in 1x Laemmli Buffer (25mM Tris-HCl pH6.8, 50mM DTT, 1% (w/v) SDS, 0.1% (w/v) Bromophenol Blue, 2.5% Glycerol).

products categories :

Human Recombinant Protein

products description :

RANTES (acronym for Regulated upon Activation, Normal T-cell Expressed, and presumably Secreted) is a member of the beta (C-C) chemokine subfamily and is predominantly produced from T cells and platelets. RANTES has been shown to be a chemoattractant factor for monocytes, CD4+/CD45RO+ T lymphocytes and basophils. It has also been shown to induce the proliferation and activation of killer cells and may act as a HIV suppressive factor. Our recombinant RANTES comprises a 68 amino acid fragment (24-91) corresponding to the mature RANTES protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

products references :

Schall, T.J. et al., (1988) J. Immunol. 141 (3): 1018-1025.

ncbi gi num :

2905632

ncbi acc num :

AAC03541.1

uniprot acc num :

P13501

ncbi mol weight :

9,990 Da

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833

ncbi summary :

This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq]

uniprot summary :

Function: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. Ref.3 Ref.8 Ref.10 Ref.11 Ref.12. Subcellular location: Secreted. Tissue specificity: T-cell and macrophage specific. Induction: By mitogens. Post-translational modification: N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in Ref.8. They are assigned by similarity. Polymorphism: The variant Phe-24 is an antagonist of the chemokine receptors CCR1 and CCR3. Sequence similarities: Belongs to the intercrine beta (chemokine CC) family. Mass spectrometry: Molecular mass is 7515 1 Da from positions 27 - 91. Determined by SELDI. Ref.12Molecular mass is 7862.8 1.1 Da from positions 24 - 91. Determined by ESI. Ref.8Molecular mass is 8355 10 Da from positions 24 - 91. Determined by ESI. O-glycosylated. Ref.8

size :

0.01 mg

price :

200 USD