P-Selectin | MyBioSource MBS343118 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

P-Selectin

catalog :

MBS343118

quantity :

0.01 mg

price :

200 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS343118

products type :

Recombinant Protein

products full name :

P-Selectin

products short name :

P-Selectin

products name syn :

P-Selectin (197-761); P-SEL, Platelet Alpha-Granule Membrane Protein, CD62, CD62P, Granulocyte Membrane Protein GRMP, GMP140, LECAM-3

other names :

P-selectin; P-selectin; P-selectin; GMP-140; OTTHUMP00000032609; OTTHUMP00000032610; OTTHUMP00000032615; OTTHUMP00000032616; OTTHUMP00000032620; OTTHUMP00000032631; OTTHUMP00000032632; OTTHUMP00000032633; granule membrane protein 140; granulocyte membrane protein; CD62 antigen-like family member P; platelet alpha-granule membrane protein; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein; selectin P (granule membrane protein 140kDa, antigen CD62); CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein

other gene names :

SELP; SELP; CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM; FLJ45155; GMRP; GRMP

uniprot entry name :

LYAM3_HUMAN

sequence length :

830

purity :

>95% by SDS-PAGE

form :

Liquid

products categories :

Human Recombinant Protein

products description :

P-Selectin belongs to a family of divalent cationdependent carbohydrate-binding glycoproteins or adhesion molecules. P-Selectin is expressed transiently on the surface of activated platelets and endothelial cells. Secreted P-selectin is thought to play a key role in the adhesion of platelets to monocytes and neutrophils during an inflammatory response. Levels of P-Selectin may be elevated in a number of pathological conditions. Our recombinant human P-selectin comprises a 566 amino acid fragment (197-761) corresponding to the cysteine rich complement control protein domain and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.

products references :

Tedder, T.F. (1995) FASEB J. 9(10): 866-873. Kappelmayer J. (2004) Clin. Chem. Lab. Med. 42(5): 475- 486.

ncbi gi num :

157419154

ncbi acc num :

NP_002996.2

ncbi gb acc num :

NM_003005.3

uniprot acc num :

P16109

ncbi mol weight :

90,834 Da

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Formation Of Platelet Plug Pathway 106029!!Hemostasis Pathway 106028!!IL-3 Signaling Pathway 198881!!IL4-mediated Signaling Events Pathway 137933!!Malaria Pathway 152665!!Malaria Pathway 152657!!Platelet Activation Pathway 106034

ncbi summary :

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq]

uniprot summary :

Function: Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Ref.7. Subunit structure: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.12 Ref.15. Subcellular location: Membrane; Single-pass type I membrane protein. Tissue specificity: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. Involvement in disease: Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [. MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Ref.20. Sequence similarities: Belongs to the selectin/LECAM family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 9 Sushi (CCP/SCR) domains.

size :

0.01 mg

price :

200 USD

more info or order :

MyBioSource product webpage